n-6: n-3 PUFA ratio is involved in regulating lipid metabolism and inflammation in pigs

文献类型： 外文期刊

第一作者： Duan, Yehui

作者： Duan, Yehui;Li, Fengna;Li, Lili;Sun, Xiaoming;Yin, Yulong;Duan, Yehui;Fan, Juexin;Sun, Xiaoming

作者机构：

关键词： n-6:n-3 ratios;PUFA;Lipid metabolism;Inflammation;Pigs

期刊名称：BRITISH JOURNAL OF NUTRITION （ 影响因子：3.718； 五年影响因子：4.816 ）

ISSN： 0007-1145

年卷期： 2014 年 111 卷 3 期

页码：

收录情况： SCI

摘要： The objective of the present study was to investigate the optimal dietary n-6:n-3 PUFA ratios that regulate lipid metabolism and inflammation in pigs. A total of ninety-six cross-bred (Large White x Landrace) growing-finishing pigs (73.8 (sem 1.6)kg) were chosen and fed one of the four isoenergetic diets with n-6:n-3 PUFA ratios of 1:1, 2.5:1, 5:1 and 10:1. The growth performance of pigs fed the diet with an n-6:n-3 PUFA ratio of 5:1 was the best, but the group fed the diet with an n-6:n-3 PUFA ratio of 1:1 had the highest muscle mass and the lowest adipose tissue mass (P<0.05). The concentrations of IL-6 and IL-1 beta of pigs fed the diet with an n-6:n-3 PUFA ratio of 1:1 were decreased compared with those of the other groups (P<0.05). The concentration of adiponectin of pigs fed the diet with an n-6:n-3 PUFA ratio of 1:1 was also markedly decreased, but the concentration of leptin was increased compared with that of the groups fed the diets with n-6:n-3 PUFA ratios of 5:1 and 10:1 (P<0.05). Additionally, the optimal dietary ratios of n-6:n-3 PUFA of 1:1 and 5:1 markedly suppressed the expression levels of lipid metabolism-related genes and proteins such as phosphoinositide-3-kinase-alpha, fatty acid transport protein-1 and PPAR gamma. They also significantly suppressed the expression levels of the inflammatory cytokines IL-1 beta, TNF-alpha and IL-6. The results indicated that the optimal n-6:n-3 PUFA ratios of 1:1 and 5:1 exerted beneficial effects on lipid metabolism and inflammatory system, leading to the availability of more energy and nutrients for high performance and homeostatic pathways.

分类号：

  • 相关文献

[1]Flaxseed oil containing flaxseed oil ester of plant sterol attenuates high-fat diet-induced hepatic steatosis in apolipoprotein-E knockout mice. Han, Hao,Ma, Hongfei,Rong, Shuang,Chen, Li,Shan, Zhilei,Liu, Liegang,Han, Hao,Ma, Hongfei,Rong, Shuang,Chen, Li,Shan, Zhilei,Liu, Liegang,Xu, Jiqu,Zhang, Yunjian.

[2]Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc(+/1638N) Mice: Comparisons and Contrasts. Liu, Wei,Lyu, Lin,Li, Jinchao,Choi, Sang-Woon,Liu, Zhenhua,Liu, Wei,Crott, Jimmy W.,Pfalzer, Anna C.,Mason, Joel B.,Liu, Zhenhua,Choi, Sang-Woon,Yang, Yingke,Mason, Joel B.. 2016

[3]INFLAMMATION-RELATED OXIDATIVE STRESS IN WHITE ADIPOSE TISSUES OF AN INBRED OBESE PIG. Yang, X. F.,Jiang, Z. Y.,Tian, Z. M.,Qiu, Y. Q.,Wang, L.,Gao, K. G.,Hu, Y. J.,Ma, X. Y.. 2017

[4]Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. Funaro, Antonietta,Wu, Xian,Song, Mingyue,Zheng, Jinkai,Guo, Shanshan,Rakariyatham, Kanyasiri,Xiao, Hang,Funaro, Antonietta,Rodriguez-Estrada, Maria Teresa,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan. 2016

[5]Koumine Attenuates Lipopolysaccaride-Stimulated Inflammation in RAW264.7 Macrophages, Coincidentally Associated with Inhibition of NF-kappa B, ERK and p38 Pathways. Wu, Jing,Sun, Zhiliang,Yuan, Zhihang,Wu, Jing,Sun, Zhiliang,Matias, Froilan Bernard,Liang, Zengenni. 2016

[6]Supplementation of black rice pigment fraction improves antioxidant and anti-inflammatory status in patients with coronary heart disease. Wang, Qing,Han, Pinghua,Zhang, Mingwei,Xia, Min,Zhu, Huilian,Ma, Jing,Hou, Mengjun,Tang, Zhihong,Ling, Wenhua. 2007

[7]Identification of porcine serum proteins modified in response to HP-PRRSV HuN4 infection by two-dimensional differential gel electrophoresis. An, Tongqing,Gong, Daqing,Peng, Jinmei,Leng, Chaoliang,Yuan, Zhonghua,Tian, Zhijun,Yang, Yongqian,Li, Dengyun,Zhang, Deli,Tong, Guangzhi. 2012

[8]Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2. Chang, Zhi-Qiang,Lee, Su-Yeon,Kim, Hye-Jin,Kim, Jung Ran,Kim, Su-Jung,Hong, In-Kyung,Oh, Byung-Chul,Choi, Cheol-Soo,Park, Tae-Sik,Chang, Zhi-Qiang,Goldberg, Ira J.. 2011

[9]Ability of Lactobacillus plantarum lipoteichoic acid to inhibit Vibrio anguillarum-induced inflammation and apoptosis in silvery pomfret (Pampus argenteus) intestinal epithelial cells. Gao, Quanxin,Min, Minghua,Zhang, Chenjie,Peng, Shiming,Shi, Zhaohong,Gao, Qian.

[10]Lychee (Litchi chinensis Sonn.) Pulp Phenolic Extract Provides Protection against Alcoholic Liver Injury in Mice by Alleviating Intestinal Microbiota Dysbiosis, Intestinal Barrier Dysfunction, and Liver Inflammation. Xiao, Juan,Zhang, Ruifen,Liu, Lei,Huang, Fei,Deng, Yuanyuan,Ma, Yongxuan,Wei, Zhencheng,Tang, Xiaojun,Zhang, Mingwei,Zhou, Qiuyun.

[11]Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. Zhao, Liang,Wang, Yong,Guo, Xiaoxuan,Ji, Baoping,Zhou, Feng,Liu, Jia,Wang, Kai,Wu, Wei.

[12]Thiamine supplementation facilitates thiamine transporter expression in the rumen epithelium and attenuates high-grain-induced inflammation in low-yielding dairy cows. Pan, X. H.,Yang, L.,Xue, F. G.,Tang, Z. W.,Xiong, B. H.,Pan, X. H.,Beckers, Y.,Jiang, L. S..

[13]Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice. Xu, Jiqu,Tian, Guangjing,Ma, Congcong,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Tian, Guangjing,Ma, Congcong,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Yang, Wei,Chen, Chang,Chen, Chang,Ma, Zhonghua.

[14]Linolelaidic acid induces apoptosis, cell cycle arrest and inflammation stronger than elaidic acid in human umbilical vein endothelial cells through lipid rafts. Li, Jing,Rao, Huan,Bin, Qiu,Fan, Ya-Wei,Li, Hong-Yan,Deng, Ze-Yuan,Rao, Huan,Bin, Qiu.

[15]Effect of Candida albicans on Intestinal Ischemia-reperfusion Injury in Rats. Yan, Lei,Wu, Chun-Rong,Yang, Chun-Hui,Tang, Jian-Guo,Wang, Chen,Tong, Guang-Zhi. 2016

[16]Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats. Xu, Jiqu,Ma, Congcong,Han, Ling,Zhou, Qi,Yang, Mei,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Ma, Congcong,Han, Ling,Zhou, Qi,Yang, Mei,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Chen, Chang,Chen, Chang. 2014

[17]Influence of dietary taurine and housing density on oviduct function in laying hens. Dai, Bin,Zhang, Yuan-shu,Zheng, Liu-hai,Li, Shuang-jie,Miao, Jin-feng,Ma, Zi-li,Dou, Xin-hong,Gong, Jian-sen. 2015

[18]Staphylococcus aureus infection of intestinal epithelial cells induces human umbilical cord-derived mesenchymal stem cell migration. Li, Yang,Liu, Ming-yuan,Wang, Xue-lin,Han, Wen-yu,Liu, Ya-hui,Suo, Jian,Li, Zhi-jie,Li, Ya-gang,Jin, Hu. 2013

[19]Flaxseed oil and alpha-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Yang, Wei. 2012

[20]Protective Effect of Total Flavones from Hippophae rhamnoides L. against Visible Light-Induced Retinal Degeneration in Pigmented Rabbits. Wang, Yong,Zhao, Liang,Wang, Ou,Guo, Xiaoxuan,Lu, Feng,Yang, Xue,Ji, Baoping,Huang, Fenghong,Deng, Qianchun,Huang, Fenghong,Deng, Qianchun,Zhang, Di.

作者其他论文 更多>>

微信小程序