Facile bubble-assisted evaporation-induced assembly of high-density arrays of Co3O4 nano/microlotus leaves: fluorescent properties, drug delivery, and biocompatibility

文献类型： 外文期刊

第一作者： Tong, Guo-Xiu

作者： Tong, Guo-Xiu;Liu, Fang-Ting;Wu, Wen-Hua;Tong, Chao-Li;Qiao, Ru;Guo, Hui-Chen;Guo, Hui-Chen

作者机构：

期刊名称：CRYSTENGCOMM （ 影响因子：3.545； 五年影响因子：3.297 ）

ISSN： 1466-8033

年卷期： 2014 年 16 卷 9 期

页码：

收录情况： SCI

摘要： High-density arrays of Co3O4 nano/microlotus leaves with excellent fluorescent properties and biocompatibility were synthesized using a facile bubble-assisted evaporation-induced approach and its potential application in drug delivery was assessed. The morphologically controlled growth of Co3O4 nano/microlotus leaf arrays could be realized by evaporating the acetone solution of cobalt nitrate hexahydrate in a tunable kinetic procedure, in which the gas bubbles generated in situ in the reaction system directed the assembly of the crystal coatings and/or the nuclei. These nano/microlotus leaf arrays were characterized by field-emission scanning electron microscopy (FE-SEM), X-ray energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), nitrogen adsorption/desorption and Brunauer-Emmett-Teller (BET) measurements. Fluorescein isothiocyanate (FITC) loaded into these nano/microlotus leaf arrays was used as a model platform to assess the efficacy of the arrays as a drug delivery tool. Its release kinetics study revealed a two-step release pattern of FITC from the nano/microlotus leaf arrays for over 24 h, with a burst release of around 83.4% of the dye just within a few hours. We envision that these Co3O4 nano/microlotus leaf arrays, with the hierarchically porous structures and high efficacy to adsorb chemicals such as the fluorescent dye FITC, could serve as a delivery vehicle for controlled release of chemicals administered into live cells, opening the potential of these arrays for a diverse range of applications including drug storage and release as well as metabolic manipulation of cells.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序