Safety evaluation of daidzein in laying hens: Part I. Effects on laying performance, clinical blood parameters, and organs development

文献类型： 外文期刊

第一作者： Shi, S. R.

作者： Shi, S. R.;Gu, H.;Chang, L. L.;Tong, H. B.;Zou, J. M.;Gu, H.;Wang, Z. Y.

作者机构：

关键词： Daidzein;Laying hens;Safety evaluation;Laying performance;Clinical blood parameters;Organs development

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2013 年 55 卷

页码：

收录情况： SCI

摘要： Daidzein, an estrogen-like product, becomes increasingly popular as a dietary supplement, particularly for postpeak-estrus animals seeking a safe natural alternative to play a role of estrogen. However, there is little available safety data of it for raisers and consumers. A subchronic laying hen safety study was conducted to examine if the high-dose daidzein could affect the safety of hens selves, including laying performance, clinical blood parameters and organs development. Seven hundred and sixty-eight 56-week-old Hyline Brown were randomly assigned to 4 groups with 8 replicates of 24 birds each and 3 weeks later fed diets supplemented with 0, 10, 50 and 100 mg of daidzein/kg for 12 weeks. The mortality was significantly decreased (P < 0.05). No treatment related adverse clinical signs were observed. Mean egg production, egg mass and feed conversion of whole experiment period was significantly influenced by dietary daidzein supplement (Pc 0.05), showing significant quadratic response to increasing dietary daidzein supplement (P = 0.029, P = 0.003 and P = 0.019, respectively). There was no statistically significant changes in haematology (P > 0.05). In clinical chemistry parameters, total protein, total cholesterol, calcium and phosphorus were significantly affected by dietary daidzein supplement (P < 0.05). The no observed adverse effect level (NOAEL) is considered to be 50 mg/kg. (C) 2013 Elsevier Ltd. All rights reserved.

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