Safety evaluation of daidzein in laying hens: Part II. Effects on calcium-related metabolism

文献类型： 外文期刊

第一作者： Gu, H.

作者： Gu, H.;Shi, S. R.;Chang, L. L.;Tong, H. B.;Zou, J. M.;Gu, H.;Wang, Z. Y.

作者机构：

关键词： Daidzein;Laying hens;Safety evaluation;Calcium metabolism

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2013 年 55 卷

页码：

收录情况： SCI

摘要： Daidzein, an estrogen-like product, has become increasingly popular as a dietary supplement, particularly for postpeak-estrus animals seeking a safe natural alternative to play a role of estrogen. However, there is little available safety data of it for raisers and consumers. A subchronic laying hensafety study has been conducted to examine if the high-dose daidzein could affect calcium-related metabolism (eggshell quality and bone mineralization). Seven hundred and sixty-eight 56-week-old Hyline Brown were randomly assigned to 4 groups with 8 replicates of 24 birds each (192 laying hensper group) and 3 weeks later fed diets supplemented with 0(control), 10, 50 and 100 mg of daidzein/kg for 12 week. Eggshell thickness, eggshell percentage, eggshell strength, eggshell Ca concentration was increased linearly with increasing dietary daidzein supplementation (P = 0.001, P = 0.007, P = 0.002 and P = 0.000, respectively). Serum Ca increased linearly with increasing dietarydaidzein supplementation (P = 0.042), and serum P showed a significant quadratic response to dietarydaidzein supplementation (P = 0.036). Bone ash and bone Ca were significantly influenced by dietarydaidzein supplementation (P < 0.05). These findings indicate that daidzein hold no observed adverse effect on calcium metabolism, but also a safe and effective food additive for calcium metabolism in animals and humans. (C) 2013 Elsevier Ltd. All rights reserved.

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