Simultaneous Determination of Triclabendazole and its Metabolites in Bovine and Goat Fat Tissues by Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Cai, Chengyuan

作者： Cai, Chengyuan;Xue, Feiqun;Wang, Zhongyan;Xiao, Sui;Zhang, Lifang;Wang, Zhongyan

作者机构：

关键词： Triclabendazole;Metabolites;Fat tissues;Residues;LC-MS/MS

期刊名称：FOOD ANALYTICAL METHODS （ 影响因子：3.366； 五年影响因子：3.07 ）

ISSN： 1936-9751

年卷期： 2012 年 5 卷 6 期

页码：

收录情况： SCI

摘要： A sensitive and reliable method for the simultaneous determination of triclabendazole, its main metabolites (triclabendazole sulfone and triclabendazole sulfoxide) and a marker residue (ketotriclabendazole) in edible ruminant fat tissues is developed and validated. Analytes are extracted from fat tissues with acetonitrile, and crude extracts are subjected to liquid-liquid extraction with n-hexane. Chromatographic separation is performed on a C-18 reversed-phase column with gradient elution. Analytes are detected by tandem quadrupole mass spectrometry after positive electrospray ionization by multiple reaction monitoring. Relative recoveries from spiked samples range from 86.1% to 114.3%, with relative standard deviations generally below 13.8%. Limits of detection and quantification for analytes are within 0.125-1.25 mu g/kg and 0.5-5 mu g/kg, respectively. The method proposed in this study was successfully applied to real sample testing.

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