Platycodin D restores the intestinal mechanicalbarrier by reducing endoplasmic reticulum stress-mediated apoptosis

文献类型： 外文期刊

第一作者： Fan, Mei-ling

作者： Fan, Mei-ling;Wei, Kun;Wei, Xiao-meng;Jiao, Li-li;Wei, Xiao-meng;Zhang, Jun-jie;Shen, Qiong;Li, Xin-dian;Wang, Zi;Li, Wei;Hou, Jin-gang;Sun, Yin-shi

作者机构：

关键词： Platycodin D; Endoplasmic reticulum stress; Cisplatin; Intestinal mechanical barrier; 4-PBA; Intestinal injury

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）

ISSN： 1756-4646

年卷期： 2022 年 99 卷

页码：

收录情况： SCI

摘要： The current study aimed to reveal the inhibitory effect of Platycodin D (PD) on intestinal cell apoptosis mediated by ER stress. Treatment with PD alleviated pathological changes of the intestine and reduced secretion of intracellular enzyme Diamine oxidase (DAO) in the upper villi of the small intestinal mucosa in Cisplatin (CP) intestinal injury model and increased expression of key protein Occludin and ZO-1 of the intestinal mechanical barrier. PD inhibited ER stress in a dose-dependent in CP-caused IEC-6 cells and the level of phosphorylation of Protein kinase R-like ERK kinase (PERK) and Eukaryotic initiation factor-2 alpha (eIF2 alpha) reduced. Besides, the ER stress inhibitor 4-PBA was used to confirm that PD alleviated the ER stress in vitro. In conclusion, PD exerted an intestinal protective effect through the inhibition of ER stress in CP-treated mice and IEC-6 cells. These data indicated that PD was a promising natural medicine for intestinal protection.

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