Myostatin downregulates the expression of basic fibroblast growth factor gene in HeLa cells

文献类型： 外文期刊

第一作者： Shang, J. H.

作者： Shang, J. H.;Liu, H. Z.;Chen, S. H.;Luo, P.

作者机构：

关键词： myostatin;basic fibroblast growth factor;HeLa cells

期刊名称：BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY （ 影响因子：1.278； 五年影响因子：1.365 ）

ISSN： 0006-9248

年卷期： 2012 年 113 卷 8 期

页码：

收录情况： SCI

摘要： Basic fibroblast growth factor (bFGF or FGF-2), a potent tumorigenic cytokine, improves cells proliferation and angiogenesis in tumor and also plays vital roles in tumor growth, metastasis as well as prognosis. Screening and application of effective cytokines against bFGF tumorigenic activity would be helpful to oncologic therapy. Myostatin, a member of transforming growth factor 13 superfamily, recently showed an antitumor activity and was reported to induce He La cells apoptosis through mitochondrion pathway. The above data raised our assumption that expression level of endogenous bFGF gene may be suppressed by exogenous myostatin in myostatin-treated He La cells. To test the hypothesis, myostatin was employed to stimulate He La cells and expressional level of endogenous bFGF gene in He La cells was detected with real-time RT-PCR and ELISA. Results of the suppressed expression level of bFGF gene in He la cells implied that myostatin may be regarded as an effective cytokine against bFGF to treat certain cancers (Fig. 3, Ref. 26). Full Text in PDF www.elis.sk.

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