Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety

文献类型： 外文期刊

第一作者： Cui, Zining

作者： Cui, Zining;Dohi, Hirofumi;Nishida, Yoshihiro;Cui, Zining;Yang, Xinling;Shi, Yanxia;Uzawa, Hirotaka;Cui, Jingrong

作者机构：

关键词： Synthesis;Glycosyl hydrazine;Glycosyl hydrazone;Antitumor activity;Antifungal activity;Toxicity

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN： 0960-894X

年卷期： 2011 年 21 卷 23 期

页码：

收录情况： SCI

摘要： Assuming that the water solubility of our previous hydrazone derivatives would improve after modification with sugars while keeping or modulating their notable biological activities, we designed and synthesized some glycosyl hydrazine and hydrazone derivatives. Bioassay results indicated that the antitumor activity of our previously prepared hydrazones reduced or disappeared after modification with sugars. On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi. Obviously, a small sugar can change the biological activity of hydrazones significantly. (C) 2011 Elsevier Ltd. All rights reserved.

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