Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-lambda 1 pathway

文献类型： 外文期刊

第一作者： Xiao, Shaobo

作者： Xiao, Shaobo;Wang, Dang;Fang, Liurong;Liu, Lizhi;Zhong, Huijuan;Chen, Quangang;Luo, Rui;Zhang, Zhongming;Chen, Huanchun;Xiao, Shaobo;Liu, Xiangtao

作者机构：

关键词： Interferon lambda 1;Foot-and-mouth disease virus;Leader proteinase

期刊名称：MOLECULAR IMMUNOLOGY （ 影响因子：4.407； 五年影响因子：4.227 ）

ISSN： 0161-5890

年卷期： 2011 年 49 卷 1-2 期

页码：

收录情况： SCI

摘要： Foot-and-mouth disease is a highly contagious viral disease caused by foot-and-mouth disease virus (FMDV) of wild and domestic cloven-hoofed animals, and causes an economically important disease in the swine industry. In this study, we found that the replication of FMDV in IBRS-2 cells could be significantly inhibited after treatment with the purified recombinant porcine interferon lambda 1 (IFN-lambda 1), a newly identified type III interferon. However, FMDV could not activate the IFN-lambda 1 promoter and IFN-lambda 1 mRNA expression in infected IBRS-2 cells, suggesting that FMDV has evolved mechanisms to interrupt the antiviral function of IFN-lambda 1. The cause of this inhibition was determined by screening all structural and non-structural proteins of FMDV, and the leader proteinase (L(pro)) was found to exhibit the highest potential to inhibit poly(I:C)-induced IFN-lambda 1 promoter activity. Further study revealed that the catalytic activity and a SAP (SAF-A/B, Acinus, and PIAS) domain of L(pro) were required for suppressing poly(I:C)-induced IFN-lambda 1 production. These data suggest that FMDV replication could be inhibited by porcine IFN-lambda 1, but that the virus has evolved specific mechanisms to inhibit this action. (C) 2011 Elsevier Ltd. All rights reserved.

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