Promising Multiple-Epitope Recombinant Vaccine against Foot-and-Mouth Disease Virus Type O in Swine

文献类型： 外文期刊

第一作者： Shao, Jun-Jun

作者： Shao, Jun-Jun;Lin, Tong;Cong, Guo-Zheng;Du, Jun-Zheng;Gao, Shan-Dian;Liu, Xiang-Tao;Cai, Xue-Peng;Chang, Hui-Yun;Liu, Ji-Xing;Wong, Chung Kai;Lee, Shuk Kwan;Sin, Fion Wai Yee;Xie, Yong

作者机构：

期刊名称：CLINICAL AND VACCINE IMMUNOLOGY （ 影响因子：3.233； 五年影响因子：2.562 ）

ISSN： 1556-6811

年卷期： 2011 年 18 卷 1 期

页码：

收录情况： SCI

摘要： In order to develop a completely safe immunogen to replace the traditional inactivated vaccine, a tandem-repeat multiple-epitope recombinant vaccine against foot-and-mouth disease (FMD) virus (FMDV) type O was developed. It contained three copies each of residues 141 to 160 and 200 to 213 of VP1 of the O/China/99 strain of FMDV coupled with a swine immunoglobulin G heavy-chain constant region (scIgG). The data showed that the multiple-epitope recombinant vaccine elicited high titers of anti-FMDV specific antibodies in swine at 30 days postvaccination (dpv) and conferred complete protection against a challenge with 10(3) 50% swine infective doses of the O/China/99 strain. The anti-FMDV specific antibody titers were not significantly different between the multiple-epitope recombinant vaccine and the traditional vaccine (t test, P > 0.05). The number of 50% pig protective doses was 6.47, which is higher than the number recommended by the World Organization for Animal Health. The multiple-epitope recombinant vaccine resulted in a duration of immunity of at least 6 months. We speculate that the multiple-epitope recombinant vaccine is a promising vaccine that may replace the traditional inactivated vaccine for the prevention and control of FMD in swine in the future.

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