Study of Oxidative Damage in Growing-Finishing Pigs with Continuous Excess Dietary Chromium Picolinate Intake

文献类型： 外文期刊

第一作者： Tan, Gao-Yi

作者： Tan, Gao-Yi;Zheng, Shan-Shan;Zhang, Min-Hong;Feng, Jing-Hai;Xie, Peng;Bi, Jin-Ming

作者机构：

关键词： Chromium picolinate;Pig;Excess;Oxidative damage

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.738； 五年影响因子：3.44 ）

ISSN： 0163-4984

年卷期： 2008 年 126 卷 1-3 期

页码：

收录情况： SCI

摘要： Chromium picolinate (CrPic) is a popular nutritional supplement; however, its safety has been questioned as it may be a source of oxidative stress that induces genotoxicity. The current work investigated the effect of excessive CrPic intake on oxidative damage in growing-finishing pigs. Thirty castrated male pigs, weighing approximately 30 kg each, were randomly divided into five groups and fed a diet with 0, 200, 800, 1,600, 3,200 mu g of Cr/kg feed as CrPic for 80 days (approximately the entire growing-finishing period). High CrPic dose significantly decreased superoxide dismutase activity in serum at 80 days as well as the catalase activity in kidney (p < 0.05); however, compared to controls, malondialdehyde in tissue and serum, urinary 8-hydroxydeoxyguanosine level, and DNA strand breaks in liver and kidney had no notable differences (p > 0.05). These results suggested that long-term exposure to different doses of CrPic in feed did not increase the formation of biomarkers of oxidative damage in growing-finishing pigs. However, taking into account the changes of antioxidant enzymes activity, excessive dietary CrPic intake was not recommended in this study.

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