Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection

文献类型： 外文期刊

第一作者： Wang, Zhilong

作者： Wang, Zhilong;Hu, Haiming;Xu, Qiuping;Zhang, Weihong;Deng, Sisi;Lv, Pingyun;Yang, Yan;Chen, Xinwen;Tang, Hong;Wang, Zhilong;Hu, Haiming;Xu, Qiuping;Zhang, Weihong;Deng, Sisi;Lv, Pingyun;Yang, Yan;Chen, Xinwen;Tang, Hong;Gao, Yanhang;Gong, Sitang;Xu, Yi;Gong, Sitang;Wang, Zhilong;Zhang, Chao;Chen, Hairong;Tang, Hong;Xu, Qiuping;Tang, Hong;Guo, Dongwei;Weng, Changjiang;Gao, Yanhang;Ding, Yanhua;Li, Qingquan;Niu, Junqi;Wang, Zhilong

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： HCV infection can decrease NAD(+)/NADH ratio, which could convert lipid metabolism to favor HCV replication. In hepatocytes, quinolinate phosphoribosyl transferase (QPRT) catabolizes quinolinic acid (QA) to nicotinic acid mononucleotide (NAMN) for de novo NAD synthesis. However, whether and how HCV modulates QPRT hence the lipogenesis is unknown. In this work, we found QPRT was reduced significantly in livers of patients or humanized C/O-Tg mice with persistent HCV infection. Mechanistic studies indicated that HCV NS3/4A promoted proteasomal degradation of QPRT through Smurf2, an E3 ubiquitin-protein ligase, in Huh7.5.1 cells. Furthermore, QPRT enzymatic activity involved in suppression of HCV replication in cells. Activation of QPRT with clofibrate (CLO) or addition of QPRT catabolite NAD both inhibited HCV replication in cells, probably through NAD(+)-dependent Sirt1 inhibition of cellular lipogenesis. More importantly, administration of CLO, a hypolipidemic drug used in clinics, could significantly reduce the viral load in HCV infected C/O-Tg mice. Take together, these results suggested that HCV infection triggered proteasomal degradation of QPRT and consequently reduced de novo NAD synthesis and lipogenesis, in favor of HCV replication. Hepatic QPRT thus likely served as a cellular factor that dampened productive HCV replication.

分类号：

  • 相关文献
作者其他论文 更多>>
  • UBE2S facilitates glioblastoma progression through activation of the NF-κB pathway via attenuating K11-linked ubiquitination of AKIP1

    作者：Han, Zhibin;Xu, Lin;Wang, Aowen;Gang, Zhenbo;Lin, Zhiguo;Hu, Li;Wang, Baoju;Liu, Qinfang;Liu, Hongyang;Weng, Changjiang;Liu, Qi;Yu, Shengkun;Mu, Long;Mu, Long

    关键词：GBM; UBE2S; AKIP1; Deubiquitination; NF-kappa B

  • Light promotes pharmacological activities of bitter gourd ( Momordica charantia ) via McHY5/McHY5-X1 and McPIF1-X1/McPIF3 antagonistic regulation in MAP30 transcription

    作者：Yu, Renbo;Liu, Jie;Han, Xu;Shi, Zhidi;Niu, Yu;Miao, Rumeng;Liu, Zhaohua;Yang, Yan;Yu, Renbo;Liu, Jie;Han, Xu;Shi, Zhidi;Niu, Yu;Miao, Rumeng;Liu, Zhaohua;Yang, Yan;Wang, Xiaoyi;Liu, Jie;Shi, Zhidi;Yu, Renbo;Han, Xu;Niu, Yu;Liu, Zhaohua;Yang, Yan

    关键词：Bitter gourd; MAP30; McHY5; McPIF3; Transcription; Promoter

  • Optimizing the Total Spikelets Increased Grain Yield in Rice

    作者：Liu, Kun;Zhang, Yu;Li, Shouguo;Zhang, Jingli;Deng, Shan;Zhang, Yiying;Huang, Jingyan;Ren, Li;Chu, Yunxia;Zhao, Hong;Chen, Hairong;Liu, Kun;Zhang, Yu;Li, Shouguo;Zhang, Jingli;Deng, Shan;Zhang, Yiying;Huang, Jingyan;Ren, Li;Chu, Yunxia;Zhao, Hong;Chen, Hairong;Zhang, Kaixi;Cui, Jiarong;Li, Zhikang;Huang, Jian

    关键词：rice (Oryza sativa L.); high yield; rice varieties with various yield types; total spikelets; total nitrogen application rate

  • Development of an analytic method for organosulfur compounds in Welsh onion and its use for nutritional quality analysis of five typical varieties in China

    作者：Liu, Pingxiang;Bi, Jingxiu;Jiang, Yuying;Gao, Rui;Gao, Lei;Zhao, Tong;Zhang, Xiao;Zhang, Chao;Wang, Yutao;Wu, Peng;Li, Yonghua

    关键词：Enzymatic inhibition; UHPLC-MS/MS; Organosulfur compound; Amino acid; Nutritional quality

  • 2023 International African Swine Fever Workshop: Critical Issues That Need to Be Addressed for ASF Control

    作者：Wang, Lihua;Li, Yuzhen;Shi, Jishu;Ganges, Llilianne;Ganges, Llilianne;Dixon, Linda K.;Netherton, Christopher L.;Reis, Ana L.;Bu, Zhigao;Zhao, Dongming;Quang Lam Truong;Richt, Juergen A.;Jin, Meilin;Peng, Guiqing;Benarafa, Charaf;Summerfield, Artur;Benarafa, Charaf;Summerfield, Artur;Benarafa, Charaf;Summerfield, Artur;Weng, Changjiang;Han, Jun;Penrith, Mary-Louise;Mo, Yupeng;Su, Zhipeng;Dang Vu Hoang;Pogranichniy, Roman M.;Balaban-Oglan, David-Adrian;Balaban-Oglan, David-Adrian;Wang, Kewen;Cai, Xuepeng

    关键词：African swine fever; workshop; platform; highlights; lessons; control; prevention

  • Genome-wide identification of the MADS-box gene family in Avena sativa and its role in photoperiod-insensitive oat

    作者：Nan, Jinsheng;An, Jianghong;Yang, Yan;Zhao, Guofen;Liu, Huiyan;Han, Bing;An, Jianghong;Yang, Xiaohong

    关键词：Avena sativa L; MADS-box gene family; Photoperiod; Short-day; Gene expression

  • Fungal diversity notes 1717-1817: taxonomic and phylogenetic contributions on genera and species of fungal taxa

    作者：Liu, Shi-Liang;Wang, Xue-Wei;Razaghi, Parisa;Raza, Mubashar;Cai, Lei;Jiang, Shuhua;Zhang, Chao;Zhou, Li-Wei;Wang, Xue-Wei;Li, Guo-Jie;Deng, Chun-Ying;Rossi, Walter;Leonardi, Marco;Liimatainen, Kare;Niskanen, Tuula;Kekki, Tapio;Smith, Matthew E.;Ammirati, Joe;Ammirati, Joe;Bojantchev, Dimitar;Abdel-Wahab, Mohamed A.;Zhang, Ming;Tian, Enjing;Bau, Tolgor;Lu, Yong-Zhong;Zhang, Jing-Yi;Ma, Jian;Zhang, Jing-Yi;Ma, Jian;Du, Tian-Ye;Peng, Xing-Can;Hyde, Kevin D.;Dutta, Arun Kumar;Acharya, Krishnendu;Saha, Rituparna;Tarafder, Entaj;Du, Tian-Ye;Du, Tian-Ye;Peng, Xing-Can;Hyde, Kevin D.;Xu, Jize;Kim, Ji Seon;Lim, Young Woon;Kim, Ji Seon;Lim, Young Woon;Gerlach, Alice;Zeng, Nian-Kai;Han, Yun-Xiao;Raza, Mubashar;Calabon, Mark S.;Jones, E. B. Gareth;Kumar, T. K. Arun;Krishnapriya, K.;Thomas, Anjitha;Kaliyaperumal, Malarvizhi;Kezo, Kezhocuyi;Gunaseelan, Sugantha;Singh, Sanjay Kumar;Singh, Paras Nath;Lagashetti, Ajay Chandrakant;Pawar, Kadambari Subhash;Rana, Shiwali;Zhang, Chao;Zhang, Huang;Qing, Yun;Peng, Xing-Can;Wen, Ting-Chi;Peng, Xing-Can;Wen, Ting-Chi;Ramirez, Natalia A.;Niveiro, Nicolas;Li, Mei-Xiang;Yang, Zhu L.;Wu, Gang;Li, Mei-Xiang;Yang, Zhu L.;Wu, Gang;Tennakoon, Danushka S.;Suwannarach, Nakarin;Kumla, Jaturong;Lumyong, Saisamorn;Tennakoon, Danushka S.;Suwannarach, Nakarin;Kumla, Jaturong;Lumyong, Saisamorn;Kuo, Chang-Hsin;da Silva, Tatiane M.;Bezerra, Jadson D. P.;Souza-Motta, Cristina M.;He, Gang;Ji, Xiao-Hong;Wannathes, Nopparat

    关键词：95 new taxa; Six new records; Ascomycota; Basidiomycota

微信小程序