Clearance or Hijack: Universal Interplay Mechanisms Between Viruses and Host Autophagy From Plants to Animals

文献类型： 外文期刊

第一作者： Wu, Wenxian

作者： Wu, Wenxian;Luo, Xiumei;Ren, Maozhi;Wu, Wenxian;Luo, Xiumei;Ren, Maozhi;Wu, Wenxian;Luo, Xiumei;Ren, Maozhi;Luo, Xiumei

作者机构：

关键词： virus-host interaction; immune response; autophagy; virus manipulation; infection

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：6.073； 五年影响因子：6.34 ）

ISSN： 2235-2988

年卷期： 2022 年 11 卷

页码：

收录情况： SCI

摘要： Viruses typically hijack the cellular machinery of their hosts for successful infection and replication, while the hosts protect themselves against viral invasion through a variety of defense responses, including autophagy, an evolutionarily ancient catabolic pathway conserved from plants to animals. Double-membrane vesicles called autophagosomes transport trapped viral cargo to lysosomes or vacuoles for degradation. However, during an ongoing evolutionary arms race, viruses have acquired a strong ability to disrupt or even exploit the autophagy machinery of their hosts for successful invasion. In this review, we analyze the universal role of autophagy in antiviral defenses in animals and plants and summarize how viruses evade host immune responses by disrupting and manipulating host autophagy. The review provides novel insights into the role of autophagy in virus-host interactions and offers potential targets for the prevention and control of viral infection in both plants and animals.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序