Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration

文献类型： 外文期刊

第一作者： Chen, Yin Bin

作者： Chen, Yin Bin;Wang, Yu Fang;Hou, Wei;Wang, Ying Ping;Xiao, Sheng Yuan;Wang, Jia;Zheng, Si Wen;Zheng, Pei He;Xiao, Sheng Yuan;Fu, Yang Yang

作者机构：

关键词： antifatigue;B-complex vitamins;bioavailability;ginsenoside Re;interaction

期刊名称：JOURNAL OF GINSENG RESEARCH （ 影响因子：6.06； 五年影响因子：5.711 ）

ISSN： 1226-8453

年卷期： 2017 年 41 卷 2 期

页码：

收录情况： SCI

摘要： Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drugenutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatographyetandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with Bcomplex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentrationetime curve from zero to infinity markedly decreasing from 11,830.85 +/- 2,366.47 h.ng/mL to 890.55 +/- 372.94 h.ng/mL. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drugenutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.

分类号：

  • 相关文献

[1]Ocean acidification increases the toxic effects of TiO2 nanoparticles on the marine microalga Chlorella vulgaris. Xia, Bin,Sui, Qi,Sun, Xuemei,Han, Qian,Chen, Bijuan,Zhu, Lin,Qu, Keming,Xia, Bin,Sun, Xuemei,Chen, Bijuan,Zhu, Lin,Xia, Bin,Sui, Qi. 2018

[2]Brain Concentration of Ginsenosides and Pharmacokinetics after Oral Administrationof Mountain-cultivated Ginseng. Li, Meijia,Guan, Yiming,Liu, Ning,Shao, Cai,Liu, Zhengbo,Chen, Jianbo,Wang, Qiuxia,Pan, Xiaoxi,Sun, Hai,Zhang, Yayu. 2017

[3]Phosphorus Adsorption and Bioavailability in a Paddy Soil Amended with Pig Manure Compost and Decaying Rice Straw. Liang, Yongchao,Guo, Bin,Liang, Yongchao,Li, Zhaojun,Han, Fengxiang. 2009

[4]Use of chemical characteristics to predict the relative bioavailability of supplemental organic manganese sources for broilers. Li, S,Luo, X,Liu, B,Crenshaw, TD,Kuang, X,Shao, G,Yu, S. 2004

[5]Preparation, characterization, bioavailability in vitro and in vivo of tea polysaccharides-iron complex. Tang, Minmin,Wang, Dongfeng,Hou, Yangfeng,Buchili, Petter,Sun, Liping. 2013

[6]Uptake of arsenic species by turnip (Brassica rapa L.) and lettuce (Lactuca sativa L.) treated with roxarsone and its metabolites in chicken manure. Yao, Li Xian,He, Zhao Huan,Zhou, Chang Min,Li, Guo Liang,Yang, Bao Mei,Huang, Lian Xi,Yao, Li Xian,He, Zhao Huan,Zhou, Chang Min,Li, Guo Liang,Yang, Bao Mei,Li, Ying Fen. 2013

[7]Structural characterization and bioavailability of ternary nanoparticles consisting of amylose, alpha-linoleic acid and beta-lactoglobulin complexed with naringin. Feng, Tao,Wang, Ke,Liu, Fangfang,Ye, Ran,Zhu, Xiao,Zhuang, Haining,Xue, Zhimin.

[8]Impact of Lipid Phase on the Bioavailability of Vitamin E in Emulsion-Based Delivery Systems: Relative Importance of Bioaccessibility, Absorption, and Transformation. Yang, Ying,Yang, Ying,Xiao, Hang,McClements, David Julian.

[9]Tissue distribution and elimination of oxytetracycline in perch Lateolabras janopicus and black seabream (Sparus macrocephalus) following oral administration. Wang, Q,Liu, Q,Li, J.

[10]Relative Bioavailability of Zinc-Methionine Chelate for Broilers Fed a Conventional Corn-Soybean Meal Diet. Suo, Haiqing,Lu, Lin,Zhang, Liyang,Luo, Xugang,Zhang, Xueyuan,Li, Hua,Lu, Yufei.

[11]Hydrophobicity exerts different effects on bioavailability and stability of antioxidant peptide fractions from casein during simulated gastrointestinal digestion and Caco-2 cell absorption. Xie, Ningning,Wang, Bo,Jiang, Liangping,Liu, Congcong,Li, Bo,Xie, Ningning,Wang, Bo,Li, Bo,Jiang, Liangping,Liu, Congcong.

[12]Charge properties of peptides derived from casein affect their bioavailability and cytoprotection against H2O2-induced oxidative stress. Wang, Bo,Li, Bo,Xie, Ningning,Li, Bo.

[13]Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake. Kalt, Wilhelmina,McDonald, Jane E.,Fillmore, Sherry A. E.,Liu, Yan.

[14]Bioavailability assessment of thiacloprid in soil as affected by biochar. Zhu, Yulong,Liu, Xingang,Wu, Xiaohu,Dong, Fengshou,Xu, Jun,Zheng, Yongquan.

[15]Relative bioavailability of manganese proteinate for broilers fed a conventional corn-soybean meal diet. Wang, Funing,Yao, Junhu,Lu, Lin,Li, Sufen,Liu, Songbai,Zhang, Liyang,Luo, Xugang,Li, Sufen.

[16]Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems. Wang, Kai,Qi, Jianping,Weng, Tengfei,Tian, Zhiqiang,Lu, Yi,Wu, Wei,Wang, Kai,Weng, Tengfei,Yin, Zongning,Wang, Kai,Hu, Kaili. 2014

[17]Relative bioavailability of iron proteinate for broilers fed a casein-dextrose diet. Ma, X. Y.,Liu, S. B.,Lu, L.,Xie, J. J.,Zhang, L. Y.,Zhang, J. H.,Luo, X. G.,Ma, X. Y.,Liu, S. B.,Li, S. F.. 2014

[18]Reduction of arsenic bioavailability by amending seven inorganic materials in arsenic contaminated soil. Sun Yuan-yuan,Zeng Xi-bai,Bai Ling-yu,Li Lian-fang,Su Shi-ming,Wang Ya-nan,Liu Rong-le,Sun Yuan-yuan,Lin Qi-mei. 2015

[19]Evaluation of biochars in reducing the bioavailability of flubendiamide in water/sediment using passive sampling with polyoxymethylene. Liu, Xingang,Wu, Xiaohu,Xu, Jun,Dong, Fengshou,Zheng, Yongquan,Liu, Xingang. 2018

[20]Mercury distribution and speciation in floodplain soils and uptake into native earthworms (Diplocardia spp.). Han, Fengxiang X.,Su, Yi,Xia, Yunjun,Tian, Wushuang,Philips, Valerie,Han, Fengxiang X.,Shi, Zhiqi,Monts, David L.,Gu, Mengmeng,Liang, Yongchao. 2012

作者其他论文 更多>>

微信小程序