Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain

文献类型: 外文期刊

第一作者: Li, Zhenguang

作者: Li, Zhenguang;He, Yanliang;Li, Shufen;Xia, Mingqi;Wu, Hua;Li, Zhenguang;Leng, Xue;Wen, Yongjun;Wang, Fengxue;Cheng, Shipeng;Wu, Hua;Xu, Xiaoqin

作者机构:

关键词: HP-PRRSV;humoral immunity;cell-mediated immunity;immune responses

期刊名称:BMC VETERINARY RESEARCH ( 影响因子:2.741; 五年影响因子:2.955 )

ISSN: 1746-6148

年卷期: 2016 年 12 卷

页码:

收录情况: SCI

摘要: Background: Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to swine industry all over the world. The aim of this study was to investigate the mechanism of pathogenesis and immune responses caused by a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). Results: All piglets experimentally infected with a HP-PRRSV TJ strain virus developed typical clinical signs of PRRS. The percentages of CD3(+), CD4(+), and CD8(+) lymphocytes significantly decreased in the infected group as compared to the uninfected control animals (p < 0.01). Total WBC dropped in the infected animals during the experiment. The level of ELISA antibody against PRRSV increased in 7-10 days after infection and then started to decline. Pathological observations demonstrated various degree lesions, bleeding and necrosis in the lungs of the infected piglets. Conclusions: These results clearly indicated that HP-PRRSV TJ strain infection would activate host humoral immune response at the early period post infection and cause severe pathological damages on lungs and inhibit cellular immune response after infection.

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