Minimum dose, antigen content, and immunization duration of a trivalent vaccine of inactivated Haemophilus parasuis serovars 4, 5, and 12 against Glasser's disease in pigs

文献类型： 外文期刊

第一作者： Zhao, Zhanqin

作者： Zhao, Zhanqin;Liu, Huisheng;Zhang, Keshan;Zhao, Zhanqin;Xue, Qiao;Chen, Kunpeng;Xue, Yun

作者机构：

期刊名称：CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE （ 影响因子：1.31； 五年影响因子：1.438 ）

ISSN： 0830-9000

年卷期： 2016 年 80 卷 4 期

页码：

收录情况： SCI

摘要： The objective of this study was to assess the minimum dose, antigen content, and immunization duration of a trivalent vaccine containing inactivated Haemophilus parasuis serovars 4, 5, and 12 and the Montanide GEL 01 PR adjuvant in piglets and pregnant sows. Our results demonstrated that the minimum vaccine dose was 2 mL per pig and the optimal antigen content 2.0 x 10(9), 1.0 x 10(9), and 1.0 x 10(9) colony-forming units/mL of serovars 4, 5, and 12, respectively. The vaccine provided effective protection 14 d after the 2nd vaccination, and the period of immune protection was 180 d (6 mo) after the 2nd vaccination. Maternal antibodies provided early protection for the piglets, and vaccinating the sows before farrowing helped to control disease and protected the piglets during lactation; the piglets were protected during the finishing period by being vaccinated during lactation. Our findings provide a basis for developing a commercial trivalent vaccine of inactivated H. parasuis serovars 4, 5, and 12 against Glasser's disease.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序