Magnolol protects channel catfish from Aeromonas hydrophila infection via inhibiting the expression of aerolysin
文献类型: 外文期刊
第一作者: Dong, Jing
作者: Dong, Jing;Ding, Hao;Liu, Yongtao;Yang, Qiuhong;Xu, Ning;Yang, Yibin;Ai, Xiaohui;Dong, Jing;Ding, Hao;Liu, Yongtao;Yang, Qiuhong;Xu, Ning;Yang, Yibin;Ai, Xiaohui
作者机构:
关键词: Hemolytic activity;Ictalurus punctatus;Pathogenicity;Virulence factor
期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )
ISSN: 0378-1135
年卷期: 2017 年 211 卷
页码:
收录情况: SCI
摘要: Aeromonas hydrophila is a common zoonotic pathogen which can cause several infections both in human and animals, particular aquatic animals. Antibiotics have been widely used in the treatment of A. hydrophila infections, however, the development of resistance has limited the treatment for these infections. There is an urgent need for novel agents and strategies against these infections. Aerolysin, a pore-forming toxin secreted by most pathogenic A. hydrophila, is known to contribute to the pathogenesis of A. hydrophila infections. Therefore, aerolysin has been identified as a potential target for drug discovery. In this paper, we found that magnolol, a natural compound without anti-A. hydrophila activity, could significantly inhibit the hemolytic activity of A. hydrophila culture supernatants by inhibiting the transcription of the aerolysin encoding gene aerA at low concentrations. Furthermore, the survival assay showed that magnolol could significantly reduce the mortality induced by A. hydrophila infection in channel catfish (Ictalurus punctatus). Taken together, these findings provide a potent agent against A hydrophila infections.
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