Aplysin Sensitizes Cancer Cells to TRAIL by Suppressing P38 MAPK/Survivin Pathway

文献类型： 外文期刊

第一作者： Liu, Jia

作者： Liu, Jia;Wu, Ning;Liu, Ge;Lin, Xiukun;Liu, Jia;Liu, Ge;Ma, Leina;Zheng, Lanhong;Lin, Xiukun

作者机构：

关键词： aplysin;TRAIL;p38 MAPK;survivin

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2014 年 12 卷 9 期

页码：

收录情况： SCI

摘要： TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-survival proteins, such as survivin, is responsible for TRAIL resistance. In this study, we found that Aplysin, a brominated compound from marine organisms, was able to restore the sensitivity of cancer cells to TRAIL both in vitro and in vivo. Aplysin was found to enhance the tumor-suppressing capacity of TRAIL on several TRAIL-resistant cancer cell lines. TRAIL-induced apoptosis was also potentiated in A549 and MCF7 cells treated with Aplysin. Survivin downregulation was identified as a mechanism by which Aplysin-mediated TRAIL sensitization of cancer cells. Furthermore, the activation of p38 MAPK was revealed in Aplysin-treated cancer cells, and its inhibitor SB203580 was able to abrogate the promoting effect of Aplysin on the response of cancer cells to TRAIL action, as evidenced by restored survivin expression, elevated cell survival and reduced apoptotic rates. In conclusion, we provided evidence that Aplysin acts as a sensitizer for TRAIL and its effect on p38 MAPK/survivin pathway may partially account for this activity. Considering its low cytotoxicity to normal cells, Aplysin may be a promising agent for cancer treatment in combination with TRAIL.

分类号：

  • 相关文献

[1]MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death. Jiao, Peng,Zhou, Yun-Sheng,Yang, Juan-Xia,Zhao, Ya-Li,Liu, Qiang-Qiang,Yuan, Chuang,Wang, Feng-Ze,Wang, Feng-Ze. 2013

[2]Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy. Wu, Yunzhou,An, Ying,Yan, Shijun,Yin, Jiechao,Li, Deshan,He, Jinjiao,Geng, Jingshu,Ye, Xianlong,Yu, Qingzhong,Zhang, Zhenyu.

[3]2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin promotes endothelial cell apoptosis through activation of EP3/p38MAPK/Bcl-2 pathway. Yu, Yu,Liu, Qian,Guo, Shumin,Kong, Deping,Yu, Ying,Yu, Yu,Liu, Qian,Guo, Shumin,Zhang, Qianqian,Tang, Juan,Liu, Guizhu,Kong, Deping,Li, Juanjuan,Yan, Shuai,Yu, Ying,Wang, Ruiguo,Wang, Peilong,Su, Xiaoou. 2017

[4]Establishment of Tetracycline-Inducible, Survivin-Expressing CHO Cell Lines by an Optimized Screening Method. Zhao, Xinghui,Yu, Yingqun,Guo, Junwei,Fu, Ling,Yu, Ting,Hou, Lihua,Yi, Shaoqiong,Chen, Wei,Yu, Yingqun,Zhao, Zhanzhong.

[5]Potential Mechanisms Involved in Ceramide-induced Apoptosis in Human Colon Cancer HT29 Cells. Wang, Jing,Du, Yu-Guo,Lv, Xiao-Wen. 2009

[6]Aberrant promoter hypermethylation of p16, survivin, and retinoblastoma in gastric cancer. Guo, L.,Huang, C.,Ji, Q. J.,Huang, C.. 2017

[7]p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid. Liu, Jia,Wu, Ning,Liu, Ge,Lin, Xiu-Kun,Zheng, Lan-Hong,Ma, Lei-Na,Liu, Ge,Lin, Xiu-Kun,Zhong, Jia-Teng. 2014

[8]Galactosylated poly(ethylene glycol) methacrylate-st-3-guanidinopropyl methacrylamide copolymers as siRNA carriers for inhibiting Survivin expression in vitro and in vivo. Wu, Yang,Qin, Zhu,Ji, Jinkai,Yang, Ran,Li, Xingsong,Qin, Zhu,Zhang, Xiaoqiang,Li, Yuanhui,Yin, Lihong,Pu, Yuepu.

[9]Regulatory role of ASK1 in porcine circovirus type 2-induced apoptosis. Wei, Li,Zhu, Shanshan,Wang, Jing,Zhang, Chunyan,Quan, Rong,Yan, Xv,Liu, Jue.

作者其他论文 更多>>

微信小程序