Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling

文献类型： 外文期刊

第一作者： Wang, Youxia

作者： Wang, Youxia;Zhang, Xinmei;Ren, Wenkai;Wang, Hao;Hung, Ifen;Liu, Chunxue;Hung, Ifen;Ge, Liangpeng;Wang, Hao

作者机构：

期刊名称：RESEARCH （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 2096-5168

年卷期： 2024 年 7 卷

页码：

收录情况： SCI

摘要： The prevalence of food allergies is increasing dramatically and causing serious public health concerns. Notably, melatonin metabolism imbalance in patients with food allergies; however, the role of melatonin in food allergies remains unclear. Here, we demonstrated that melatonin suppresses food allergy responses and reprograms the gut microbiota of food-allergic mice, while melatonin aggravates food allergy during gut microbiota depletion. Mechanistically, melatonin boosts the degranulation of mast cells by up-regulating the expression of membrane high-affinity immunoglobulin E (IgE) receptor (Fc epsilon RI). Melatonin increases the mRNA expression of Rabenosyn-5 (a component of factors for endosome recycling and Rab interactions) through melatonin receptor 2 (MT2)-extracellular signal-regulated kinase (ERK) signaling, thereby driving the recycling of Fc epsilon RI and elevating the abundance of membrane Fc epsilon RI. Likewise, the inhibition of MT2 attenuates melatonin-induced food allergy in mice with gut microbiota depletion. Collectively, our finding provides insights into the pathogenesis of food allergies and provides a potential therapeutic target for the prevention and treatment of food allergies.

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