Intergenerational inheritance of quercetin-induced abnormal immunity in mice

文献类型： 外文期刊

第一作者： Zheng, Xuanyu

作者： Zheng, Xuanyu;Xiao, Jianbo;Huang, Wenqi;Farag, Mohamed A.;Xiao, Jianbo;Li, Chunlin;Li, Chunlin

作者机构：

关键词： Quercetin; intergenerational inheritance; epigenetic; immune function; infection

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：8.8； 五年影响因子：12.0 ）

ISSN： 1040-8398

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Quercetin, a dietary flavonol enriched in food, regulates immune-related models through epigenetic modifications. However, few studies have explored the transmission of regulatory effects across generations to the progeny. Here, we selected Escherichia coli, a conditional pathogen capable of causing gastrointestinal infections or various localized tissue and organ infections under specific conditions, as the pathogenic strain to infect mice. We provide evidence that quercetin can not only induce responsiveness changes against systemic E. coli infection in directly exposed organisms, but also in subsequent generations through the transgenerational inheritance of epigenetic traits. Both parental male mice and their progeny exhibited cellular and phenotypic changes associated with metabolic alterations. Surprisingly, the male and female progeny of mice treated with quercetin (200 mg/kg) for six weeks negatively enhanced the survival rate under systemic E. coli (1 x 108 CFU/mL) infection, concurrent with an increase in bacterial loads in the liver and spleen. Serum TNF-alpha and IL-1 beta levels significantly increased post-infection in the progeny. Our results provide the first evidence of the inheritance of immunity driven by quercetin in mammals and the attenuation of protection against bacterial infection.

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