A missense mutation in RRM1 contributes to animal tameness

文献类型： 外文期刊

第一作者： Dou, Mingle

作者： Dou, Mingle;Li, Ming;Zheng, Zhuqing;Chen, Qiuming;Wang, Jinxin;Shan, Huiquan;Wang, Fei;Dai, Xuelei;Li, Yunjia;Yang, Zhirui;Tan, Guanghui;Luo, Funong;Wu, Jiang Wei;Nanaei, Hojjat Asadollahpour;Niyazbekova, Zhannur;Wang, Xihong;Jiang, Yu;Li, Ming;Zheng, Zhuqing;Zheng, Zhuqing;Chen, Qiuming;Wu, Yongji;Zhao, Shanting;Chen, Lei;Wang, Wen;Shi, Yun Stone;Luo, Xiong-Jian;Nanaei, Hojjat Asadollahpour;Zhang, Guojie;Wang, Wen;Zheng, Wenxin;Jiang, Yu

作者机构：

期刊名称：SCIENCE ADVANCES （ 影响因子：13.6； 五年影响因子：15.4 ）

ISSN： 2375-2548

年卷期： 2023 年 9 卷 25 期

页码：

收录情况： SCI

摘要： The increased tameness to reduce avoidance of human in wild animals has been long proposed as the key step of animal domestication. The tameness is a complex behavior trait and largely determined by genetic factors. However, the underlying genetic mutations remain vague and how they influence the animal behaviors is yet to be explored. Behavior tests of a wild-domestic hybrid goat population indicate the locus under strongest artificial selection during domestication may exert a huge effect on the flight distance. Within this locus, only one missense mutation RRM1(I241V) which was present in the early domestic goat similar to 6500 years ago. Genome editing of RRM1(I241V) in mice showed increased tameness and sociability and reduced anxiety. These behavioral changes induced by RRM1(I241V) were modulated by the alternation of activity of glutamatergic synapse and some other synapse-related pathways. This study established a link between RRM1(I241V) and tameness, demonstrating that the complex behavioral change can be achieved by mutations under strong selection during animal domestication.

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