The N-glycosylation at positions 652 and 661 of viral spike protein negatively modulates porcine deltacoronavirus entry

文献类型： 外文期刊

第一作者： Wang, Hai-Ming

作者： Wang, Hai-Ming;Qiao, Yang-Yang;Cai, Bing-Yan;Lu, Hui;Liu, Yong-Gang;Yang, Yue-Lin;Tang, Yan-Dong;Tang, Yan-Dong

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关键词： PDCoV; N-glycosylation; entry; pseudotyped virus; spike protein

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：2.6； 五年影响因子：3.1 ）

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年卷期： 2024 年 11 卷

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收录情况： SCI

摘要： N-glycosylation is a highly conserved glycan modification that plays crucial roles in various physiological processes, including protein folding, trafficking, and signal transduction. Porcine deltacoronavirus (PDCoV) poses a newly emerging threat to the global porcine industry. The spike protein of PDCoV exhibits a high level of N-glycosylation; however, its role in viral infection remains poorly understood. In this study, we applied a lentivirus-based entry reporter system to investigate the role of N-glycosylation on the viral spike protein during PDCoV entry stage. Our findings demonstrate that N-glycosylation at positions 652 and 661 of the viral spike protein significantly reduces the infectivity of PDCoV pseudotyped virus. Overall, our results unveil a novel function of N-glycosylation in PDCoV infection, highlighting its potential for facilitating the development of antiviral strategies.

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