Novel technologies are turning a dream into reality: conditionally replicating viruses as vaccines

文献类型： 外文期刊

第一作者： Tang, Yan-Dong

作者： Tang, Yan-Dong;Cai, Xue-Hui;Yu, Changqing;Tang, Yan-Dong;Cai, Xue-Hui;Tang, Yan-Dong

作者机构：

期刊名称：TRENDS IN MICROBIOLOGY （ 影响因子：15.9； 五年影响因子：18.6 ）

ISSN： 0966-842X

年卷期： 2024 年 32 卷 3 期

页码：

收录情况： SCI

摘要： Conditionally replicating viruses (CRVs) are a type of virus with one or more essential gene functions that are impaired resulting in the disruption of viral genome replication, protein synthesis, or virus particle assembly. CRVs can replicate only if the deficient essential genes are supplied. CRVs are widely used in biomedical research, particularly as vaccines. Traditionally, CRVs are generated by creating complementary cell lines that provide the impaired genes. With the development of biotechnology, novel techniques have been invented to generate CRVs, such as targeted protein degradation (TPD) technologies and premature termination codon (PTC) read-through technologies. The advantages and disadvantages of these novel technologies are discussed. Finally, we provide perspectives on what challenges need to be overcome for CRVs to reach the market.

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