Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size

文献类型： 外文期刊

第一作者： He, Qinghao

作者： He, Qinghao;Li, Yu;Hu, Ligang;Jiang, Guibin;Lu, Jing;Shang, Chao;Li, Xiao;Liu, Nian;Hu, Ligang;Jiang, Guibin;Lu, Wenqing;Hu, Ligang

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关键词： AgNPs; SARS-CoV-2; cell activity; viral replication

期刊名称：NANOMATERIALS （ 影响因子：5.719； 五年影响因子：5.81 ）

ISSN：

年卷期： 2022 年 12 卷 6 期

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收录情况： SCI

摘要： Coronavirus disease 2019 (COVID-19) has spread rapidly and led to over 5 million deaths to date globally. Due to the successively emerging mutant strains, therapeutics and prevention against the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are urgently needed. Prevention of SARS-CoV-2 infection in public and hospital areas is essential to reduce the frequency of infections. Silver nanoparticles (AgNPs) with virucidal effects have been reported. Therefore, we investigated the virucidal activity and safety of ten types of AgNPs with different surface modifications and particle sizes, in cells exposed to SARS-CoV-2 in vitro. The AgNPs could effectively inhibit the activity of SARS-CoV-2, and different surface modifications and particle sizes conferred different virucidal effects, of which 50-nm BPEI showed the strongest antiviral effect. We concluded that the efficacy of each type of AgNP type was positively correlated with the corresponding potential difference (R-2 = 0.82). These in vitro experimental data provide scientific support for the development of therapeutics against COVID-19, as well as a research basis for the development of broad-spectrum virucides. Given the increasing acquired resistance of pathogens against conventional chemical and antibody-based drugs, AgNPs may well be a possible solution for cutting off the route of transmission, either as an external material or a potential medicine.

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