Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

文献类型： 外文期刊

第一作者： Peng, Hanyang

作者： Peng, Hanyang;Zeng, Yanbo;Yang, Li;Wu, Fei;Gai, Cuijuan;Yuan, Jingzhe;Chang, Wenjun;Dai, Haofu;Peng, Hanyang;Zeng, Yanbo;Yang, Li;Wu, Fei;Gai, Cuijuan;Yuan, Jingzhe;Chang, Wenjun;Dai, Haofu;Peng, Hanyang;Zhang, Rui;Wang, Xiachang;Zeng, Yanbo

作者机构：

关键词： soft coral; cembranoid diterpene; structural elucidation; absolute configuration; anti-inflammatory activity

期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.6 ）

ISSN：

年卷期： 2024 年 22 卷 12 期

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收录情况： SCI

摘要： Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A-E (1-5), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6-10). The structures and absolute configuration for new compounds 1-5 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.

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