Genomic similarity and antibody-dependent enhancement of immune serum potentially affect the protective efficacy of commercial MLV vaccines against NADC30-like PRRSV

文献类型： 外文期刊

第一作者： Li, Yang

作者： Li, Yang;Zheng, Zifang;Li, Zhiwei;Ma, Zhiqian;Zheng, Haixue;Xiao, Shuqi;Xu, Lele;Jiao, Dian;Chen, Zhihao;Jing, Yang;Li, Zhiwei;Feng, Yingtong;Guo, Xuyang;Wang, Yumiao;He, Yuan

作者机构：

关键词： NADC30-like PRRSV; Modified live virus (MLV) vaccines; Genomic similarity; Antibody dependent enhancement (ADE); Cross protection

期刊名称：VIROLOGICA SINICA （ 影响因子：5.5； 五年影响因子：4.9 ）

ISSN： 1674-0769

年卷期： 2023 年 38 卷 5 期

页码：

收录情况： SCI

摘要： Porcine reproductive and respiratory syndrome (PRRS) is one of the most significant diseases affecting the pig industry worldwide. The PRRSV mutation rate is the highest among the RNA viruses. To date, NADC30-like PRRSV and highly pathogenic PRRSV (HP-PRRSV) are the dominant epidemic strains in China; however, com-mercial vaccines do not always provide sufficient cross-protection, and the reasons for insufficient protection are unclear. This study isolated a wild-type NADC30-like PRRSV, SX-YL1806, from Shaanxi Province. Vaccination challenge experiments in piglets showed that commercial modified live virus (MLV) vaccines provided good protection against HP-PRRSV. However, it could not provide sufficient protection against the novel strain SX-YL1806. To explore the reasons for this phenomenon, we compared the genomic homology between the MLV strain and HP-PRRSV or NADC30-like PRRSV and found that the MLV strain had a lower genome similarity with NADC30-like PRRSV. Serum neutralization assay showed that MLV-immune serum slightly promoted the ho-mologous HP-PRRSV replication and significantly promoted the heterologous NADC30-like PRRSV strain repli-cation in vitro, suggesting that antibody-dependent enhancement (ADE) might also play a role in decreasing MLV protective efficacy. These findings expand our understanding of the potential factors affecting the protective effect of PRRSV MLV vaccines against the NADC30-like strains.

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