A novel activatable AIEgen fluorescent probe for peroxynitrite detection and its application in EC1 cells

文献类型： 外文期刊

第一作者： Han, Xiaojing

作者： Han, Xiaojing;Yang, Xiaopeng;Zhang, Yongru;Li, Zipeng;Ye, Yong;Zhang, Di;Cao, Wenbo

作者机构：

关键词： AIE fluorescent probe; Long emission wavelength; Peroxynitrite; Cell imaging

期刊名称：SENSORS AND ACTUATORS B-CHEMICAL （ 影响因子：7.46； 五年影响因子：6.743 ）

ISSN：

年卷期： 2020 年 321 卷

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收录情况： SCI

摘要： Peroxynitrite (ONOO-), as one type of reactive nitrogen species (RNS), is closely related to multiple pathophysiological processes. Visualization of ONOO- in living system is essential for further study of its physiological functions. However, most existing ONOO- fluorescent probes continuously display the aggregation-caused quenching (ACQ). In present research, a new activatable AIEgen fluorescent probe QM-ONOO- for ONOO- recognition and imaging was proposed. Activation of the probe by ONOO-, induced aggregation of QM-OH. This sensor showed fast response time (< 4 min) and high sensitivity (DL, 27.5 nM), large Stock's shift (190 nm), long emission wavelength. Furthermore, the outcomes indicate that QM-ONOO- as an activatable AIEgen fluorescent sensor was robust chemical tool to detect endogenous peroxynitrite in living biological system.

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