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Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats

文献类型：外文期刊

第一作者： Chen, Wanchao

作者： Chen, Wanchao;Wu, Di;Li, Qiaozhen;Liu, Yanfang;Zhang, Jingsong;Li, Zhengpeng;Yang, Yan;Jin, Yueling;Qiao, Xuxin;Dong, Guochao;Li, Tingting

作者机构：

关键词： Hericium erinaceus; Purified polysaccharide; Gastroprotective activity; Gastric ulcer

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （影响因子：6.953；五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2020 年 159 卷

页码：

收录情况： SCI

摘要： The beta-glucan H6PC20 (Mw: 2390 kDa) and alpha-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and cor-responding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, macroscopic and histological evaluation of gastric mucosa was improved significantly. The defense and repair factors (EGF, bFGF and PGE2) were increased, mean-while, the inflammatory cytokines (IL-1 beta and TNF-alpha) and MDA were reduced. These results indicated that H6PC20 and HPB-3 presented gastroprotective activities with the mechanism of activating repair and defense system, decreasing the inflammatory response and alleviating the oxidative injury. Furthermore, the structure -activity relationship showed that the macromolecular beta-glucan was better for repair and defense system, while the low weight molecular alpha-heteropolysaccharide focused on the anti-inflammatory effect. The polysac-charides purified from H. erinaceus can be developed as a potential gastroprotective ingredient for applications in pharmaceutical field. (C) 2020 Published by Elsevier B.V.

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