Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats
文献类型： 外文期刊
第一作者： Chen, Wanchao
作者： Chen, Wanchao;Wu, Di;Li, Qiaozhen;Liu, Yanfang;Zhang, Jingsong;Li, Zhengpeng;Yang, Yan;Jin, Yueling;Qiao, Xuxin;Dong, Guochao;Li, Tingting
作者机构：
关键词： Hericium erinaceus; Purified polysaccharide; Gastroprotective activity; Gastric ulcer
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2020 年 159 卷
页码：
收录情况： SCI
摘要： The beta-glucan H6PC20 (Mw: 2390 kDa) and alpha-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and cor-responding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, macroscopic and histological evaluation of gastric mucosa was improved significantly. The defense and repair factors (EGF, bFGF and PGE2) were increased, mean-while, the inflammatory cytokines (IL-1 beta and TNF-alpha) and MDA were reduced. These results indicated that H6PC20 and HPB-3 presented gastroprotective activities with the mechanism of activating repair and defense system, decreasing the inflammatory response and alleviating the oxidative injury. Furthermore, the structure -activity relationship showed that the macromolecular beta-glucan was better for repair and defense system, while the low weight molecular alpha-heteropolysaccharide focused on the anti-inflammatory effect. The polysac-charides purified from H. erinaceus can be developed as a potential gastroprotective ingredient for applications in pharmaceutical field. (C) 2020 Published by Elsevier B.V.
分类号：
- 相关文献
作者其他论文 更多>>
-
Tradeoff between productivity and stability across above- and below-ground communities
作者：Hu, Zonghao;Liu, Haiyan;Pang, Shuang;Li, Tingting;Yang, Wei;Zhang, Ximei;Yang, Junjie;Han, Xingguo;Hua, Bin;Bahn, Michael;Wu, Honghui;Wu, Honghui
关键词：grassland restoration; microbial biomass; nitrogen deposition; productivity; stability
-
Light promotes pharmacological activities of bitter gourd ( Momordica charantia ) via McHY5/McHY5-X1 and McPIF1-X1/McPIF3 antagonistic regulation in MAP30 transcription
作者：Yu, Renbo;Liu, Jie;Han, Xu;Shi, Zhidi;Niu, Yu;Miao, Rumeng;Liu, Zhaohua;Yang, Yan;Yu, Renbo;Liu, Jie;Han, Xu;Shi, Zhidi;Niu, Yu;Miao, Rumeng;Liu, Zhaohua;Yang, Yan;Wang, Xiaoyi;Liu, Jie;Shi, Zhidi;Yu, Renbo;Han, Xu;Niu, Yu;Liu, Zhaohua;Yang, Yan
关键词：Bitter gourd; MAP30; McHY5; McPIF3; Transcription; Promoter
-
Tetrazolium viability test method for micro-seeds of the endangered plant Deinanthe caerulea
作者：Xu, Jie;Li, Tingting;Wang, Zhengxiang;Xiao, Pengnan;Chen, Chuanhong;Wang, Xiangming;Chen, Bangqing
关键词：endangered plant; micro-seeds; plant conservation; seed germination; seed viability; tetrazolium staining
-
Alternate feeding between high- and low- carbohydrate based diets improves the growth digestive capacity, liver glycometabolism for common carp (Cyprinus carpio)
作者：Fan, Ze;Wu, Di;Li, Chenhui;Li, Jinnan;Wang, Liansheng;Zheng, Xianhu;Zhang, Haitao;Zhou, Meng;Fan, Ze;Wu, Di;Li, Chenhui;Li, Jinnan;Wang, Liansheng;Zheng, Xianhu;Zhou, Meng
关键词：Alternate feeding; High-carbohydrate diets; Low-carbohydrate diets; Growth; Glycometabolism; Common carp
-
Genome-wide identification of the MADS-box gene family in Avena sativa and its role in photoperiod-insensitive oat
作者：Nan, Jinsheng;An, Jianghong;Yang, Yan;Zhao, Guofen;Liu, Huiyan;Han, Bing;An, Jianghong;Yang, Xiaohong
关键词：Avena sativa L; MADS-box gene family; Photoperiod; Short-day; Gene expression
-
Effects of an efficient straw decomposition system mediated by Stropharia rugosoannulata on soil properties and microbial communities in forestland
作者：Hao, Haibo;Yue, Yihong;Yang, Yan;Wang, Qian;Xiao, Tingting;Chen, Hui;Zhang, Jinjing;Hao, Haibo;Kuai, Benke;Hao, Haibo;Kuai, Benke;Chen, Qun
关键词：Stropharia rugosoannulata; Spent mushroom substrate; Soil nutrients; Microbial community; Co-occurrence networks; Structural equation model
-
Transient anoxic conditions boost N2O emissions by stimulating denitrification capacity and decreasing N2O reduction ratio in soils with different carbon substrates
作者：Zhuang, Shan;Ding, Junjun;Kou, Xinyue;Li, Qiaozhen;Xu, Chunying;Mao, Lili;Pan, Yanshuo;Li, Yuzhong;Zhuang, Shan;Han, Dongfei;Ding, Junjun;Li, Qiaozhen;Xu, Chunying;Mao, Lili;Li, Yuzhong;Lin, Wei;Zheng, Qian;Gao, Ying;Gao, Ying;Ding, Junjun;Han, Dongfei
关键词：Nitrous oxide; Transient anoxic conditions; Oxalic acid; Serine; Glucose; N2O reduction; Dual isotope mapping
