Effect of pyriproxyfen exposure on cocooning and gene expression in the silk gland of Bombyx mori (Linnaeus, 1758)

文献类型： 外文期刊

第一作者： Zhao, Guodong

作者： Zhao, Guodong;Zhang, Xiao;Wang, Chentao;Zhang, Haitao;Guo, Huimin;Qian, Heying;Li, Gang;Xu, Anying;Zhao, Guodong;Qian, Heying;Li, Gang;Xu, Anying;Xu, Anying

作者机构：

关键词： Bombyx mori; Silk gland; Pyriproxyfen; Cocooning; Gene expression

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2020 年 202 卷

页码：

收录情况： SCI

摘要： Bombyx mori(Linnaeus, 1758) is an important economical insect, and the sericulture is a flourishing industry in many developing countries. Pyriproxyfen, a juvenile hormone pesticide, is often applied to cultivations widely in the world, and its exposure often resulted in silk yield reduction and non-cocooning. However, the effect of pyriproxyfen exposure on cocooning and gene expression level in the silk gland of B. mori has not been studied yet, and this study focused on the above issues. The result indicated that pyriproxyfen exposure can lead to silk gland injury, reduction of silk yield and cocooning rate. Furthermore, the expression levels of silk protein synthesis related genes were down regulated significantly. The same change trends were shown between PI3K/Akt and CncC/Keap1 pathway, which is the expressions of key genes can be elevated by pyriproxyfen exposure. In addition, the activity of detoxification enzymes (P450, GST and CarE) and the expression levels of detoxification genes were elevated after pyriproxyfen exposure, suggesting that detoxification enzymes may play an important role in detoxification of pyriproxyfen in silk gland. These results provided possible clues to the silk gland injury and gene transcriptional level changes in silkworm after pyriproxyfen exposure.

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