NLRP3 played a role inTrichinella spiralis-triggered Th2 and regulatory T cells response

文献类型： 外文期刊

第一作者： Jin, Xuemin

作者： Jin, Xuemin;Bai, Xue;Yang, Yong;Ding, Jing;Liu, Mingyuan;Liu, Xiaolei;Shi, Haining;Fu, Baoquan;Boireau, Pascal;Liu, Mingyuan

作者机构：

关键词： Trichinella spiralis; excretory-secretory products; dendritic cell; NLRP3; Th2; Treg

期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）

ISSN： 0928-4249

年卷期： 2020 年 51 卷 1 期

页码：

收录情况： SCI

摘要： Trichinella spiralismaintains chronic infections within its host. Muscle larvae excretory-secretory products (MLES) typically induce parasite-specific immune responses such as the Th2 response and regulatory T cells (Tregs) by modulating dendritic cell (DC) phenotype via the recognition of pattern recognition receptors (PRRs), such as Nod-like receptors (NLRs). We aimed to investigate the role of NLRP3 inT. spiralis-triggered immune response. We found that larvae burden was increased in NLRP3(-/-)mice compared to wild type (WT) mice. Administration of MLES induced higher levels of IL-4, IL-10, TGF-beta and population of Tregs in WT mice than in NLRP3(-/-)mice. In vitro, we showed that increased expression of CD40 on the surface of MLES-treated DCs was inhibited after NLRP3 knockout. Increased production of IL-1 beta, IL-18, IL-10 and TGF-beta, but not IL-12p70, was significantly diminished in the absence of NLRP3. Furthermore, our results demonstrated that MLES-treated DCs induced higher levels of IL-4, IL-10 and TGF-beta and populations of Tregs in vitro. These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response. Taken together, we identified for the first time the involvement of NLRP3 in host defences againstT. spiralis.

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