Isolation and Cytotoxicity of Isocoumarins from the Entomogenous FungusSetosphaeriasp.

文献类型： 外文期刊

第一作者： Liu, Sha-Sha

作者： Liu, Sha-Sha;Gao, Wen-Bin;Kang, Jie;Yang, Xiao-Hui;Cao, Fei;Luo, Du-Qiang;Kong, Fan-Dong;Zhao, You-Xing

作者机构：

关键词： Setosphaeriasp; isocoumarins; cytotoxicity

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.809； 五年影响因子：0.708 ）

ISSN： 0009-3130

年卷期： 2020 年 56 卷 5 期

页码：

收录情况： SCI

摘要： A new isocoumarin compound named setosphacohol A (1), together with six known ones, alternariol (2), isoaltenuene (3), phomasatin (4), alternariol 5-O-methyl ether (5), 1-deoxyrubralactone (6), and rubralactone (7), was isolated from the entomogenous fungus Setosphaeria sp. The structure of the new compound was elucidated by analysis of the 1D and 2D spectroscopic data as well as MS. Compounds2,5,6showed moderate cytotoxicity against six human tumor cell lines MCF-7, MGC-803, H1975, Huh-7, A549, and HeLa with IC(50)values ranging from 23.04 to 96.91 mu g center dot mL(-1).

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