Tryptophan Promotes the Production of Xanthophyll Compounds in Yellow Abdominal Fat through HAAO

文献类型： 外文期刊

第一作者： Liu, Xiaojing

作者： Liu, Xiaojing;Men, Lilin;Chen, Yanji;Wang, Yongli;Wang, Yanke;Zhang, Xu;Cui, Huanxian;Wen, Jie;Liu, Xiaojing;Guo, Yuming

作者机构：

关键词： chicken; abdominal fat color; xanthophyll compounds; tryptophan; HAAO

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.0 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 11 期

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收录情况： SCI

摘要： The abdominal fat of broiler chickens was used as one of the important parts for color evaluation, which directly affects the market price and demand of broilers. This study aimed to identify the contributors and the regulatory network involved in the formation of yellow and white color in abdominal fat. Four xanthophyll compounds were generally significantly correlated with eight metabolites. The high expression of 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) in the yellow abdominal fat group leads to the degradation of tryptophan and its intermediate 5-hydroxyindole compounds, and subsequently to the formation of the four xanthophyll compounds. This study provides a genetic theoretical basis for improving the external appearance and internal quality of chicken abdominal fat. Abdominal fat, which in the past was often regarded as waste and discarded, has in recent years been used as a fat source to produce meat by-products. Yellow abdominal fat has higher economic value. Therefore, improving the color of abdominal fat plays an important role in improving the appearance of meat products. This study aimed to identify the contributors and the regulatory network involved in the formation of yellow and white color in abdominal fat. We found that four xanthophyll compounds were significantly different in yellow and white abdominal fat chicken, including zeaxanthin, lutein, canthaxanthin, and beta-cryptoxanthin. There were 551 different and 8 common metabolites significantly correlated with these 4 xanthophyll compounds. Similarly, a total of 54 common genes were identified in 4 common related pathways (Complement and coagulation cascades, Metabolic pathways, PPAR signaling pathway, Carbon metabolism) of the 8 common metabolites. The high expression of HAAO in the yellow abdominal fat group leads to the degradation of tryptophan and its intermediate 5-hydroxyindole, and subsequently to the formation of the four xanthophyll compounds. This process is also regulated by tyrosine, kynurenine 3-monooxygenase (KMO), homogentisate 1, 2-dioxygenase (HGD), etc. Together, these findings show the effect of tryptophan on abdominal fat color, as well as a negative regulatory effect of HAAO and 5-hydroxyindole on the production of xanthophyll compounds involved in abdominal fat coloration.

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