Telomere-to-telomere assembly of cassava genome reveals the evolution of cassava and divergence of allelic expression

文献类型： 外文期刊

第一作者： Xu, Xin-Dong

作者： Xu, Xin-Dong;Zhao, Ru-Peng;Gao, Min;Luo, Yu-Hong;Zhou, Zu-Wen;Ye, Si-Ying;Qian, Yong-Qing;Fan, Bing-Liang;Chen, Ling-Ling;Song, Jia-Ming;Xiao, Liang;Lu, Liuying;Shang, Xiaohong;Shi, Pingli;Zeng, Wendan;Cao, Sheng;Wu, Zhengdan;Yan, Huabing

作者机构：

期刊名称：HORTICULTURE RESEARCH （ 影响因子：8.7； 五年影响因子：9.0 ）

ISSN： 2662-6810

年卷期： 2023 年 10 卷 11 期

页码：

收录情况： SCI

摘要： Cassava is a crucial crop that makes a significant contribution to ensuring human food security. However, high-quality telomere-to-telomere cassava genomes have not been available up to now, which has restricted the progress of haploid molecular breeding for cassava. In this study, we constructed two nearly complete haploid resolved genomes and an integrated, telomere-to-telomere gap-free reference genome of an excellent cassava variety, 'Xinxuan 048', thereby providing a new high-quality genomic resource. Furthermore, the evolutionary history of several species within the Euphorbiaceae family was revealed. Through comparative analysis of haploid genomes, it was found that two haploid genomes had extensive differences in linear structure, transcriptome features, and epigenetic characteristics. Genes located within the highly divergent regions and differentially expressed alleles are enriched in the functions of auxin response and the starch synthesis pathway. The high heterozygosity of cassava 'Xinxuan 048' leads to rapid trait segregation in the first selfed generation. This study provides a theoretical basis and genomic resource for molecular breeding of cassava haploids.

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