Intrapulmonary Vaccination Induces Long-lasting and Effective Pulmonary Immunity Against Staphylococcus aureus Pneumonia

文献类型： 外文期刊

第一作者： Fan, Xin

作者： Fan, Xin;Li, Ning;Xu, Meiyi;Wang, Beinan;Xu, Meiyi;Wang, Beinan;Yang, Decheng

作者机构：

关键词： Staphylococcus aureus pneumonia; intrapulmonary immunization; lung tissue resident memory T cells; long-term protection

期刊名称：JOURNAL OF INFECTIOUS DISEASES （ 影响因子：5.226； 五年影响因子：5.802 ）

ISSN： 0022-1899

年卷期： 2021 年 224 卷 5 期

页码：

收录情况： SCI

摘要： Background. Staphylococcus aureus causes community- and hospital-acquired pneumonia linked to a high mortality rate. The emergence and rapid transmission of multidrug-resistant S. aureus strains has become a serious health concern, highlighting the challenges associated with the development of a vaccine to combat S. aureus pneumonia. Methods. This study evaluated the effects of intrapulmonary immunization on the immune response and protection against S. aureus lung infection in a respiratory mouse model using a subunit vaccine. Results. Compared with the intranasal immunized mice, the intrapulmonarily immunized mice had lower levels of pulmonary bacterial colonization and lethality, accompanied by alleviated lung inflammation with reduced proinflammatory cytokines and increased levels of interleukin-10 and antimicrobial peptide following intrapulmonary challenge. Optimal protection was associated with i ncreased pulmonary antibodies and resident memory T cells. Moreover, intrapulmonary immunization provided long-lasting pulmonary protection for at least 6 months, with persistent cellular and humoral immunity in the lungs. Conclusions. Vaccine reaching the deep lung by intrapulmonary immunization plays a significant role in the induction of efficacious and long-lasting immunity against S. aureus in the lung parenchyma. Hence, intrapulmonary immunization can be a strategy for the development of a vaccine against S. aureus pneumonia.

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