Determination of sulfonamide antibiotics in forage grasses by an improved QuEChERS and multi-plug filtration cleanup method combined with UHPLC-MS/MS

文献类型： 外文期刊

第一作者： Xie, Min

作者： Xie, Min;Xu, Jun;Fei, Dan;Guang, Ye-Lan;Zhou, Yao-Min;Xu, Jun;Li, Fan;Hu, Li-Zhen

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期刊名称：RSC ADVANCES （ 影响因子：4.6； 五年影响因子：4.3 ）

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年卷期： 2024 年 14 卷 46 期

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收录情况： SCI

摘要： An improved QuEChERS method combined with Multi-Plug Filtration Cleanup (m-PFC) clean-up procedure was developed for the simultaneous determination of 16 different sulfonamides in forage grasses using ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). The forage grass sample was extracted with 0.1 mol L-1 Na(2)EDTA-Mcllvaine buffer and acetonitrile solution, purified by the Navo U-QuE column tube, separated by Agilent ZORBAX Eclipse Plus C-18 column, and analyzed by MRM (multiple reaction monitoring) mode and the internal standard method was utilized for quantification. The 16 different sulfonamides display good linearity within the range of 0.5-50 mu g L-1 (R-2 > 0.9967), the limit of detection was 0.02-0.5 mu g kg(-1), and the limit of quantification was 0.05-1.0 mu g kg(-1). Under the additive amounts of 1, 2, and 10 mu g kg(-1), the recoveries were in the range of 72.3-116.9%, and the relative standard deviation was between 1.4% and 10.3%. The presented method showed the advantages of simple operation, excellent selectivity and high sensitivity. It was well-suited for both qualitative and quantitative analyses of sulfonamides in forage grass. Overall, this method provided a scientific basis for risk assessment, enforcement of quality and safety standards, and detection of sulfonamide residues in forage grass for import and export.

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