Flammulina velutipes mycorrhizae dietary fiber improves lipid metabolism disorders in obese mice through activating AMPK signaling pathway mediated by gut microbiota

文献类型： 外文期刊

第一作者： Wang, Wenliang

作者： Wang, Wenliang;Yang, Shifa;Song, Shasha;Zhang, Jian;Jia, Fengjuan;Wang, Wenliang;Song, Shasha;Zhang, Jian;Jia, Fengjuan;Wang, Wenliang;Song, Shasha;Zhang, Jian;Jia, Fengjuan;Wang, Wenliang;Song, Shasha;Zhang, Jian;Jia, Fengjuan

作者机构：

关键词： Flammulina velutipes mycorrhizae; Dietary fiber; Obese mice; Gut microbiota; AMPK signaling Pathway

期刊名称：FOOD BIOSCIENCE （ 影响因子：4.24； 五年影响因子：4.805 ）

ISSN： 2212-4292

年卷期： 2021 年 43 卷

页码：

收录情况： SCI

摘要： Mounting evidence shows that dietary fiber (DF) alleviates lipid metabolism disorders in humans and animals by regulating the gut microbiota. However, its action mechanisms remain to be elucidated. Flammulina velutipes (F. velutipes) as an edible mushroom is widely cultivated in China and has medicinal values. As a by-product of F. velutipes, the mycorrhizae are rich in high-quality DF and therefore can be used to prepare F. velutipes DF (Fv-DF). The objective of this research aimed to explore whether and how Fv-DF attenuates lipid metabolism disorders in obese mice through the gut microbiota. Here, an obese mice model induced by high-fat diet was established to analyze the effect of Fv-DF supplementation on the lipid metabolism disorders and gut microbiota. The results showed that Fv-DF administration significantly reduced the weight gain, triglycerides and total cholesterol, low-density lipoprotein cholesterol and markedly increased the activity of enzymes related to scavenging ability of oxygen free radicals. The gut microbiota sequencing exhibited that the Fv-DF supplementation increased the level of gut beneficial bacteria, such as Prevotellaceae UCG-001 and Alloprevotella. Western blot analysis revealed the phosphorylated adenosine 5'-monophosphate (AMP)-activated protein kinase (p-AMPK alpha) was up-regulated, indicating that AMPK signaling pathway was activated. The activated pathway down-regulated the fatty acid synthase level to decrease lipid synthesis and up-regulated the carnitine palmitoyl transferase-1 level to increase lipid degradation. Altogether, Fv-DF supplementation alleviates lipid metabolism disorders in obese mice by regulating the gut microbiota-mediated AMPK signaling pathway.

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[1]Flammulina velutipes mycorrhizae dietary fiber improves lipid metabolism disorders in obese mice through activating AMPK signaling pathway mediated by gut microbiota. Wang, Wenliang,Yang, Shifa,Song, Shasha,Zhang, Jian,Jia, Fengjuan,Wang, Wenliang,Song, Shasha,Zhang, Jian,Jia, Fengjuan,Wang, Wenliang,Song, Shasha,Zhang, Jian,Jia, Fengjuan,Wang, Wenliang,Song, Shasha,Zhang, Jian,Jia, Fengjuan. 2021

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