Involvement of the neddylation modification system in Bombyx mori nucleopolyhedrovirus replication

文献类型： 外文期刊

第一作者： Shen, Rui

作者： Shen, Rui;Cao, Zhijun;Huang, Jinshan;Zhang, Yiling;Shen, Zhongyuan;Tang, Xudong;Shen, Rui;Huang, Jinshan;Zhang, Yiling;Shen, Zhongyuan;Tang, Xudong;Lu, Dingding

作者机构：

关键词： baculovirus; BmNPV; MLN4924; NEDD8; neddylation

期刊名称：ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：2.454； 五年影响因子：2.11 ）

ISSN： 0739-4462

年卷期： 2022 年 110 卷 4 期

页码：

收录情况： SCI

摘要： Neddylation is a posttranslational modification that is similar to ubiquitination, and involved in some critical biological processes, such as DNA repair, transcription regulation, and ubiquitin-proteasome pathway. Recently, it was found that neddylation inhibitor MLN4924 has potent antiviral activity against human viruses including herpes simplex virus (HSV)-1, HSV-2, and influenza viruses. Here, we report that MLN4924 could dramatically and dose-dependently inhibits the propagation, formation of budding virus (BV) and occlusion body (OB) of a lepidopteran virus-Bombyx mori nucleopolyhedrovirus (BmNPV), impaired OB assembly. In addition, the neddylation modification protein NEDD8 is colocalized with aggresome and autophagosome. Our findings suggest that inhibiting neddylation could be an antibaculovirus strategy and MLN4924 may be used as candidate drug for that purpose.

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