Hybrid Diterpenic Meroterpenoids from an Endophytic Penicillium sp. Induced by Chemical Epigenetic Manipulation

文献类型： 外文期刊

第一作者： Li, Changyan

作者： Li, Changyan;Shao, Yating;Li, Wei;Li, Hongtao;Guo, Xingyi;Liu, Bo;He, Bo;Li, Changyan;Shao, Yating;Li, Wei;Li, Hongtao;Guo, Xingyi;Liu, Bo;He, Bo;Yin, Tianpeng;Yan, Hui

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）

ISSN： 0163-3864

年卷期： 2022 年 85 卷 6 期

页码：

收录情况： SCI

摘要： Cultivation of an endophytic fungus Penicillium sp. KMU18029 with suberanilohydroxamic acid (SAHA), a histone deacetylase inhibitor, led to the isolation of two pairs of diterpenic meroterpenoids with a unique natural product framework combining features of pyripyropenes and decaturins/oxalicines, pyrandecarurins A (1) and B (2), pileotin A (3) and B (4), along with their potential precursor decaturenoid (5). Compounds 1, 2, 4, and 5 were new. The structures of 1 -5 were elucidated by extensive spectroscopic analyses. The absolute configurations of 1 -4 were determined by single-crystal X-ray diffraction, NOESY spectra, ECD calculations, and biogenetic considerations. The absolute configuration of compound 3 was confirmed for the first time. Compound 5 showed moderate activity against AChE with an IC50 value of 13.9 +/- 1.1 mu M.

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