Perspective: A proposal on solutions of modern supply chain construction for lactoferrin

文献类型： 外文期刊

第一作者： Mao, Ruoyu

作者： Mao, Ruoyu;Ma, Xuanxuan;Hao, Ya;Pen, Guihong;Zheng, Xueling;Yang, Na;Teng, Da;Wang, Jianhua;Mao, Ruoyu;Ma, Xuanxuan;Hao, Ya;Pen, Guihong;Zheng, Xueling;Yang, Na;Teng, Da;Wang, Jianhua;Mao, Ruoyu;Hao, Ya;Yang, Na;Teng, Da;Wang, Jianhua

作者机构：

关键词： lactoferrin; supply chain construction; niche market; recombinant expression

期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：3.5； 五年影响因子：4.2 ）

ISSN： 0022-0302

年卷期： 2023 年 106 卷 11 期

页码：

收录情况： SCI

摘要： Lactoferrin is an iron-binding glycoprotein of the transferrin family that is found in most bodily flu-ids of mammals and has a variety of biological and beneficial functions, with great importance in health enhancement as a supplement for humans and other animals. More than 300 t of lactoferrin were produced in 2021, and this number is expected to grow yearly by 10% to 12%, to over 580 t in 2030. With new and important functions of lactoferrin being revealed and studied, focus on its industrial production and appli-cation is increasing accordingly. However, lactoferrin is mainly sourced from cheese whey or skim milk by cation-exchange column chromatography, which is a costly and low-quality method. A potential solution for lactoferrin global supply chain construction is proposed in this article as a complement to traditional routes of purification from whey or skim milk. The large-scale production of lactoferrin, mainly by recombinant yeast, mammal, and grain systems, as well as the market niche and product design, are discussed.

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