Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

文献类型： 外文期刊

第一作者： Wang, Wenqi

作者： Wang, Wenqi;Wang, Wenqi;Jin, Qiushi;Liu, Ruixue;Zhu, Pengfei;Li, Tingting;Wang, Tiecheng;Xiang, Haiyang;Xia, Xianzhu;Wang, Xuefeng;Gao, Yuwei;Jin, Qiushi;Xia, Xianzhu;Liu, Ruixue;Zhu, Pengfei;Yan, Fang;Gao, Yuwei;Zeng, Wentao;Li, Tingting;Chen, Qin;Gao, Yun;Lai, Yana;Li, Jianmin;Zhang, Hang

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关键词： SARS-CoV-2; Omicron; BA.5; spike; pathogenicity; animal models

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：5.9； 五年影响因子：6.8 ）

ISSN： 1664-3224

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： With the prevalence of sequentially-emerged sublineages including BA.1, BA.2 and BA.5, SARS-CoV-2 Omicron infection has transformed into a regional epidemic disease. As a sublineage of BA.5, the BA.5.2.48 outbroke and evolved into multi-subvariants in China without clearly established virological characteristics. Here, we evaluated the virological characteristics of two isolates of the prevalent BA.5.2.48 subvariant, DY.2 and DY.1.1 (a subvariant of DY.1). Compared to the normal BA.5 spike, the double-mutated DY.1.1 spike demonstrates efficient cleavage, reduced fusogenicity and higher hACE2 binding affinity. BA.5.2.48 demonstrated enhanced airborne transmission capacity than BA.2 in hamsters. The pathogenicity of BA.5.2.48 is greater than BA.2, as revealed in Omicron-lethal H11-K18-hACE2 rodents. In both na & iuml;ve and convalescent hamsters, DY.1.1 shows stronger fitness than DY.2 in hamster turbinates. Thus regional outbreaking of BA.5.2.48 promotes the multidirectional evolution of its subvariants, gaining either enhanced pathogenicity or a fitness in upper airways which is associated with higher transmission.

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