Inhibition of cholesterol biosynthesis promotes the production of 1-octe- n-3-ol through mevalonic acid
文献类型： 外文期刊
第一作者： Jin, Yuxi
作者： Jin, Yuxi;Yuan, Xiaoya;Wen, Jie;Cui, Huanxian;Zhao, Guiping;Jin, Yuxi;Liu, Jianfeng;Jin, Yuxi;Liu, Jianfeng
作者机构：
关键词： Chicken; Volatile organic components; Mushroom odor; Steroid hormone biosynthesis pathway; Regulated genes
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：7.425； 五年影响因子：7.716 ）
ISSN： 0963-9969
年卷期： 2022 年 158 卷
页码：
收录情况： SCI
摘要： 1-Octen-3-ol makes an important contribution to meat flavor. The goal of this study was to identify the metabolic pathways of 1-octen-3-ol formation in meat. We found 218 metabolites associated with 1-octen-3-ol content in 20 samples of chicken meat, including mevalonic acid (positive correlation), corticosterone (negative correlation), and other lipids and lipid-like molecules. Among these 218 metabolites, 17 metabolites were differentially expressed in different 1-octen-3-ol content groups. Similarly, 37 genes were not only differentially expressed, but were significantly correlated with 1-octen-3-ol. The regulation of HSP90AA1, PTPN9, and other genes converted more mevalonic acid to 1-octen-3-ol. Meanwhile, mevalonic acid, a key material in the synthesis of cholesterol, caused a decrease in corticosterone content, affecting ZNF414 and KLF15 gene expression. These findings reveal the effect of cholesterol on 1-octen-3-ol content, as well as a positive regulation of mevalonic acid on the production of 1-octen-3-ol in chicken meat.
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