Three new diterpenoids from the twigs and leaves of Croton laui

文献类型: 外文期刊

第一作者: Yang, Chengmin

作者: Yang, Chengmin;Gao, Shuyi;He, Di;Liu, Shoubai;Chen, Huiqin;Wang, Hao;Cai, Caihong;Mei, Wenli;Dai, Haofu

作者机构: Hainan Univ, Sch Forestry, Key Lab Genet & Germplasm Innovat Trop Special For, Minist Educ,Hainan Key Lab Biol Trop Specif Orname, Haikou 570228, Peoples R China;Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 570228, Peoples R China

关键词: Croton laui; Euphorbiaceae; Diterpenoids; Cytotoxic activity

期刊名称:PHYTOCHEMISTRY LETTERS ( 2022影响因子:1.7; 五年影响因子:1.8 )

ISSN: 1874-3900

年卷期: 2023 年 53 卷

页码:

收录情况: SCI

摘要: Three new diterpenoids, including one trachylobane (1) and two labdanes (2-3), were isolated from the aerial parts of Croton laui. Their structures were determined by analysis of their spectroscopic data. The absolute configuration of compound 1 was established by single-crystal X-ray diffraction analysis. Compounds 1-3 were assessed for cytotoxicity against A549, BEL-7402, SGC-7901, and Hela cell lines by the MTT assay. Compound 1 showed weak activity against the four human cancer cell lines with IC50 values of 36.09-93.94 mu M.

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