Quantitative analysis of osteoprotegerin and RANKL expression in osteoblast grown on different calcium phosphate ceramics

文献类型： 外文期刊

第一作者： Wang, CY

作者： Wang, CY;Duan, YR;Markovic, B;Barbara, J;Howlett, CR;Zhang, XD;Zreiqat, H

作者机构：

关键词： calcium phosphate ceramics;phase composition;OPG;RANKL;osteoblast

期刊名称：BIOCERAMICS, VOL 16 （ 影响因子：0.224； ）

ISSN： 1013-9826

年卷期： 2004 年 254-2 卷

页码：

收录情况： SCI

摘要： Calcium phosphate ceramics are well-known biomaterials used in orthopaedic and dental applications as bone substitute. In this study, SaOS-2 cells were grown on calcium phosphate ceramics with different phase composition for 3 and 6 days, RANKL and OPG mRNA expression were detected with quantitative in situ hybridization technique. Result showed that Saos-2 grown on tricalcium phosphate and a biphasic calcium phosphate ceramics with high tricalcium phosphate ratio expressed higher RANKL mRNA after 6 days culture. There is no significant difference in OPG expression on different surfaces after 3 days and 6 days culture. It can be concluded that tricalcium phosphate ceramics may induce more bone remodeling than hydroxyapatite when implanted in vivo.

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