Anti-inflammatory and intestinal microbiota modulation properties of Ganoderma lucidum ???????β-D-glucans with different molecular weight in an ulcerative colitis model

文献类型： 外文期刊

第一作者： Liu, Liping

作者： Liu, Liping;Feng, Jie;Jiang, Siqi;Zhou, Shuai;Yan, Mengqiu;Zhang, Zhong;Wang, Wenhan;Liu, Yanfang;Zhang, Jingsong

作者机构：

关键词： Ganoderma lucidum; beta-D-glucans; Molecular weight; Anti-inflammatory activity; Intestinal microbiota regulation; SCFAs metabolism

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 251 卷

页码：

收录情况： SCI

摘要： This study systematically investigated the therapeutic effects and the corresponding mechanisms of ss-D-glucans from Ganoderma lucidum (G. lucidum) with different molecular weights (M(w)s) on ulcerative colitis (UC). Results showed that three beta-D-glucans (GLPS, GLPN and GLPW) from G. lucidum with different Mws exhibited the significant activities on the reduction of typical symptoms of UC by regulating inflammatory cytokine levels, modulating intestinal immunity, improving intestinal microbiota and metabolism of short-chain fatty acids (SCFAs) in the dextran sulfate sodium (DSS)-induced mice model. Among them, the effects of the microwave assisted degraded fraction (GLPW) mainly containing two fractions with smaller M-w (1.33 x 10(4) and 3.51 x 10(3) g/mol) on the regulation of inflammatory factors and SCFAs metabolism were found to be comparable to those of GLPN with medium M-w (3.49 x 10(4) g/mol), and superior to those of GLPS with large M-w (2.42 x 10(6) g/mol). The effect of GLPW on regulation of intestinal microbiota was even better than that of GLPN. These findings suggested that lowering M-w by means of physical degradation could improve the anti-inflammatory activities of G. lucidum beta-D-glucans. The analysis of anti-inflammatory mechanism also provided a feasible and theoretical basis for potential use of degraded beta-D-glucans in the prevention and treatment of UC.

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