Integration of selection signatures and multi-trait GWAS reveals polygenic genetic architecture of carcass traits in beef cattle

文献类型： 外文期刊

第一作者： Niu, Qunhao

作者： Niu, Qunhao;Zhang, Tianliu;Xu, Ling;Wang, Tianzhen;Wang, Zezhao;Zhu, Bo;Zhang, Lupei;Gao, Huijiang;Li, Junya;Xu, Lingyang;Song, Jiuzhou

作者机构：

关键词： Genetic architecture; Selection signatures; Imputed sequence variants; Carcass traits; Beef cattle

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2021 年 113 卷 5 期

页码：

收录情况： SCI

摘要： Carcass merits are widely considered as economically important traits affecting beef production in the beef cattle industry. However, the genetic basis of carcass traits remains to be well understood. Here, we applied multiple methods, including the Composite of Likelihood Ratio (CLR) and Genome-wide Association Study (GWAS), to explore the selection signatures and candidate variants affecting carcass traits. We identified 11,600 selected regions overlapping with 2214 candidate genes, and most of those were enriched in binding and gene regulation. Notably, we identified 66 and 110 potential variants significantly associated with carcass traits using single-trait and multi-traits analyses, respectively. By integrating selection signatures with single and multi-traits associations, we identified 12 and 27 putative genes, respectively. Several highly conserved missense variants were identified in OR5M13D, NCAPG, and TEX2. Our study supported polygenic genetic architecture of carcass traits and provided novel insights into the genetic basis of complex traits in beef cattle.

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