MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF

文献类型： 外文期刊

第一作者： Wang, Peisong

作者： Wang, Peisong;Meng, Xianying;Liu, Jia;Wang, Guimin;Meng, Wei;Xue, Shuai;Zhang, Qiang;Chen, Guang;Huang, Yan;Lv, Zhi;Zhang, Pengju

作者机构：

关键词： miR-497;thyroid cancer;BDNF;tumorigenesis;metastasis

期刊名称：ONCOTARGET （ 影响因子：5.168； 五年影响因子：5.312 ）

ISSN： 1949-2553

年卷期： 2017 年 8 卷 2 期

页码：

收录情况： SCI

摘要： miR-497 reportedly plays critical roles in tumor development and progression in many types of cancers. We therefore investigated the function and underlying mechanism of miR-497 in thyroid cancer. We found that miR-497 is downregulated in thyroid cancer tissues, and that miR-497 levels are negatively correlated with advanced clinical stage and lymph node metastasis. Overexpressed miR-497 suppressed thyroid cancer cell proliferation, colony formation, migration, and invasion in vitro, and inhibited tumorigenesis in vivo. Moreover, brain-derived neurotrophic factor (BDNF), a known oncogene, was confirmed as a direct target of miR-497 in thyroid cancer cells. miR-497 overexpression suppressed BDNF expression and its downstream pathway(PI3K/AKT) in vitro and in vivo. BDNF levels were upregulated and inversely correlated with miR-497 levels in human thyroid cancer specimens. Rescue experiments showed that forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-497. These results show that miR-497 is a thyroid cancer tumor suppressor that acts by repressing BDNF.

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