Effects of Lactobacillus plantarum-Fermented Feed on Growth and Intestinal Health in Haliotis discus hannai

文献类型： 外文期刊

第一作者： Ke, Ling

作者： Ke, Ling;Huang, Chenyu;Peng, Song;Zhao, Mengshi;Lin, Fengqiang;Li, Zhaolong

作者机构：

关键词： Haliotis discus hannai; Lactobacillus plantarum; fermented feed; growth; intestinal health

期刊名称：MICROORGANISMS （ 影响因子：4.2； 五年影响因子：4.6 ）

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年卷期： 2025 年 13 卷 7 期

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收录情况： SCI

摘要： This study multidimensionally investigates the comprehensive effects of Lactobacillus plantarum (LP)-fermented feed on growth performance, intestinal health, and metabolic regulation in Pacific abalone (Haliotis discus hannai). The results demonstrate that LP fermentation significantly alters feed's physical properties and nutritional profile, softening texture, increasing viscosity, and emitting an acidic aroma. Notably, it enhanced contents of cis-9-palmitoleic acid, alpha-linolenic acid (ALA), and functional amino acids (GABA, L-histidine, and L-asparagine), indicating that fermentation optimized omega-3 fatty acid accumulation and amino acid profiles through the modulation of fatty acid metabolic pathways, thereby improving feed biofunctionality and stress-resistant potential. Further analyses revealed that fermented feed markedly improved intestinal morphology in abalone, promoting villus integrity and upregulating tight junction proteins (ZO-1, Claudin) to reinforce intestinal barrier function. Concurrently, it downregulated inflammatory cytokines (TNF-alpha, NF-kappa B, IL-16) while upregulating anti-inflammatory factors (TLR4) and antioxidant-related genes (NRF2/KEAP1 pathway), synergistically mitigating intestinal inflammation and enhancing antioxidant capacity. Sequencing and untargeted metabolomics unveiled that fermented feed substantially remodeled gut microbiota structure, increasing Firmicutes abundance while reducing Bacteroidetes, with the notable enrichment of beneficial genera such as Mycoplasma. Metabolite profiling highlighted the significant activation of lipid metabolism, tryptophan pathway, and coenzyme A biosynthesis. A Spearman correlation analysis identified microbiota-metabolite interactions (such as Halomonas' association with isethionic acid) potentially driving growth performance via metabolic microenvironment regulation. In conclusion, LP-fermented feed enhances abalone growth, immune response, and aquaculture efficiency through multi-dimensional synergistic mechanisms (nutritional optimization, intestinal homeostasis regulation, microbiota-metabolome crosstalk), providing critical theoretical foundations for aquafeed development and probiotic applications in aquaculture.

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