Influence of Selenium on Hepatic Antioxidant Capacity in Ducklings Intoxicated with Afatoxin B-1

文献类型： 外文期刊

第一作者： Shi, D. Y.

作者： Shi, D. Y.;Su, R. S.;Lin, R. Q.;Lin, Y. C.;Tang, Z. X.;Guo, S. N.;Liao, S. Q.

作者机构：

关键词： Selenium;hepatic antioxidant capacity;afatoxin B-1;activity;ducklings;dysfunction

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2012 年 11 卷 7 期

页码：

收录情况： SCI

摘要： To investigate the influence of selenium on hepatic antioxidant capacity in ducklings administrated with Afatoxin B-1 (AFB(1)), ninety 7 days old ducklings were randomly divided into three groups (groups I-III). Group I was wed as a blank control. Group II was administered with AFB(1) (0.1 mg kg(-1) body weight). Group III was administered with AFB(1) (0.1 mg kg(-1) body weight) plus selenium (sodium selenite, 1 mg kg(-1) body weight). All treatments were given once daily for 21 days. The results showed that the activity of hepatic Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-Px) and Glutathione Reductase (GR) in group II ducklings significantly decreased when compared with group I (p < 0.01). Furthermore, the content of hepatic Malondialdehyde (MDA) significantly increased (p < 0.01). However, the activities of hepatic SOD, CAT, GSH-Px and GR in group III ducklings significantly increased when compared with group II (p < 0.05). In addition, the content of hepatic MDA significantly decreased (p < 0.01). These results revealed that AFB(1) significantly induced hepatic antioxidant function dysfunction. However, selenium could significantly alleyiat the negative effect induced by AFB(1).

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