Immunoglobulin profiles in a murine intermediate host model of resistance for Echinococcus granulosus infection

文献类型： 外文期刊

第一作者： Zhang, WB

作者： Zhang, WB;You, H;Li, J;Zhang, ZZ;Turson, G;Aili, H;Wang, JC;McManus, DP

作者机构：

关键词： Echinococcus granulosus;murine model of resistance;oncospheres;primary infection;secondary infection;immunoglobulin profiles;antibodies;Antigen B

期刊名称：PARASITE IMMUNOLOGY （ 影响因子：2.28； 五年影响因子：3.195 ）

ISSN： 0141-9838

年卷期： 2003 年 25 卷 3 期

页码：

收录情况： SCI

摘要： We have shown previously that primary infection of Chinese Kunming (CKM) mice with Echinococcus granulosus oncospheres is protective against subsequent challenge. Nine groups of mice were infected with the oncospheres of E. granulosus by different routes (intraperitoneal, subcutaneous or intravenous injection). After infection, serum was collected after different periods of time and serum antibodies were tested by ELISA against oncospheral proteins and hydatid cyst fluid antigens. The results indicated that CKM mice produced low levels of antibodies before a secondary challenge infection given 3 weeks later by a different route. Most mice did not evoke significant antibody responses against oncospheral antigens until 5 weeks after infection. The level of IgG, especially IgG1 against oncospheral antigens increased from week 4 post-infection (p.i.), to a maximum at week 9 p.i. In addition, antibodies against hydatid cyst fluid antigens increased at the same time as the recognition of oncospheral antigens. Immunoblots using hydatid cyst fluid showed that the first antigen that was recognized - an 8-kDa protein, possibly the smallest subunit of Antigen B - appeared 5-6 weeks p.i. and reactivity to this molecule was intensive at week 9 p.i. The results suggest that protection against secondary infection was not principally antibody-mediated during the initial phases of infection, when cellular immune responses may play a pivotal role in the protective mechanism.

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