Short report: Echinococcus granulosus from Xinjiang, PR China: cDNAS encoding the EG95 vaccine antigen are expressed in different life cycle stages and are conserved in the oncosphere

文献类型： 外文期刊

第一作者： Zhang, WB

作者： Zhang, WB;Li, J;You, H;Zhang, ZZ;Turson, G;Loukas, A;McManus, DP

作者机构：

期刊名称：AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE （ 影响因子：2.345； 五年影响因子：2.799 ）

ISSN： 0002-9637

年卷期： 2003 年 68 卷 1 期

页码：

收录情况： SCI

摘要： The EG95-based vaccine protects sheep from infection with the dog tapeworm Echinococcus granulosus. The EG95 encoding gene is a member of a multigene family, several members of which are expressed in the oncosphere, believed to be the target of immunity induced by the vaccine. E. granulosus exhibits extensive intraspecific (strain) variation, and variability of the eg95 gene in different isolates of E. granulosus may directly impact the effectiveness of the EG95-based vaccine. We analyzed the eg95 gene from E. granulosus collected in Xinjiang, in northwest China, where hydatid disease is hyperendemic. The gene is expressed in oncospheres, protoscoleces, and immature and mature adult worms, and the eg95 gene family was shown to comprise two basic sequence types. Very limited sequence variation was evident in the EG95 protein from oncospheres. This high degree of sequence conservation predicts that the vaccine will continue to be effective in China and elsewhere.

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